Cytokines Recombinant Proteins

Rat IL 5 Recombinant Protein (RPPB0518)

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RPPB0518

Description

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Product Name:Rat IL 5 Recombinant Protein
Product Code:RPPB0518
Size:10µg
Species:Rat
Target:IL 5
Synonyms:EDF, BCDFII, TRF, T-cell replacing factor, Eosinophil differentiation factor, B cell differentiation factor I, IL-5.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation:Lyophilized from a concentrated (1mg/ml) solution in water containing no additives.
Solubility:It is recommended to reconstitute the lyophilized Interleikin-5 Rat in sterile 18M?-cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions.
Stability:Lyophilized Interleukin-5 Rat although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution IL5 Rat should be stored at 4°C between 2-7 days and for future use below -18°C.Please avoid freeze thaw cycles.
Purity:Greater than 95.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE.
Amino Acid Sequence:The sequence of the first five N-terminal amino acids was determined and was found to be Met-Glu-Ile-Pro-Met
Biological Activity:The ED50 range=0.3-1.0 ng/ml as determined by the dose-dependant stimulation of the proliferation of BCL-1 cells.

The protein encoded by this gene is a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. This cytokine is a main regulator of eosinopoiesis, eosinophil maturation and activation. The elevated production of this cytokine is reported to be related to asthma or hypereosinophilic syndromes. The receptor of this cytokine is a heterodimer, whose beta subunit is shared with the receptors for interleukine 3 (IL3) and colony stimulating factor 2 (CSF2/GM-CSF). This gene, together with those for interleukin 4 (IL4), interleukin 13 (IL13), and CSF2, form a cytokine gene cluster on chromosome 5. This cytokine, IL4, and IL13 are found to be regulated coordinately by long-range regulatory elements spread over 120 kilobases on chromosome 5q31.

Interleukin-5 Rat Recombinant produced in E.Coli is a dimeric, non-glycosylated polypeptide chain containing 113 amino acids and having a molecular mass of 13074 Dalton.The IL-5 is purified by proprietary chromatographic techniques.

UniProt Protein Function:Factor that induces terminal differentiation of late-developing B-cells to immunoglobulin secreting cells.
NCBI Summary:cytokine with B-cell growth factor activity [RGD, Feb 2006]
UniProt Code:Q08125
NCBI GenInfo Identifier:585311
NCBI Gene ID:24497
NCBI Accession:Q08125.1
UniProt Related Accession:Q08125
Molecular Weight:15,207 Da
NCBI Full Name:Interleukin-5
NCBI Synonym Full Names:interleukin 5
NCBI Official Symbol:Il5��
NCBI Protein Information:interleukin-5
UniProt Protein Name:Interleukin-5
UniProt Synonym Protein Names:B-cell growth factor II; BCGF-II; Cytotoxic T-lymphocyte inducer; Eosinophil differentiation factor; T-cell replacing factor; TRF
Protein Family:Interleukin
UniProt Gene Name:Il5��
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Additional Information

Product Type:
Recombinant Protein
Species:
Rat
Uniprot:
Q08125
Research Area:
Cytokines
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