Cytokines Recombinant Proteins
Rat IL 33 Recombinant Protein (RPPB0667)
- SKU:
- RPPB0667
- Product Type:
- Recombinant Protein
- Species:
- Rat
- Uniprot:
- Q66H70
- Research Area:
- Cytokines
Description
| Product Name: | Rat IL 33 Recombinant Protein |
| Product Code: | RPPB0667 |
| Size: | 10µg |
| Species: | Rat |
| Target: | IL 33 |
| Synonyms: | Interleukin 33, DVS27, NF-HEV, NKHEV, C9orf26, Interleukin-1 family member 11, IL- 1F11, Nuclear factor from high endothelial venules, NFEHEV, DKFZp586H0523, RP11-575C20.2, IL-33. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | Lyophilized from a 0.2�m filtered concentrated solution in PBS, pH 7.4. |
| Solubility: | It is recommended to reconstitute the lyophilized�IL-33 in sterile 18M-cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions. |
| Stability: | Lyophilized IL-33 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution IL-33 should be stored at 4°C between 2-7 days and for future use below -18°C.Please prevent freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | SIQGTSLLTE SCALSTYNDQ SVSFVLENGC YVINVEDCGK NQEKDKVLLR YYESSFPAQS GDGVDGKKLM VNMSPIKDTD IWLNANDKDY SVELQKGDVS PPDQAFFVLH KKSSDFVSFE CKNLPGTYIG VKDNQLALVE ENDESCNNIM FKLSKM |
| Biological Activity: | The ED50 was determined by the dose-dependent stimulation of the proliferation of murine D10S cells is <0.5ng/ml, corresponding to a specific activity of >2,000,000units/mg. |
Interleukin 33 (IL-33) is a 32kDa proinflammatory cytokine that may also regulate gene transcription in producer cells. IL-33 is structurally related to IL-1, which induces helper T cells to produce type 2 cytokines and acts through the receptor IL1RL-1 (IL1 receptor-like-1), which is known also as ST2. Binding of IL-33 to this receptor activates NF-kappa-B and MAP kinases and induces in vitro Th2 cells to produce cytokines. In vivo, IL-33 induces expression of IL-4, IL-5, IL-13 and leads to severe pathological changes in mucosal organs and in vitro, it can be divided to N-terminal fragment of 12kDa and C-terminal fragment of 18kDa by cleavage of caspase-1.
IL 33 Rat Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 156 amino acids and having a molecular mass of 17.4kDa.The IL 33 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | Function: Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as a chemoattractant for Th2 cells, and may function as an "alarmin", that amplifies immune responses during tissue injury |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q66H70 |
| NCBI GenInfo Identifier: | 62079057 |
| NCBI Gene ID: | 361749 |
| NCBI Accession: | NP_001014188.1 |
| UniProt Secondary Accession: | Q66H70 |
| UniProt Related Accession: | Q66H70 |
| Molecular Weight: | 29,486 Da |
| NCBI Full Name: | interleukin-33 |
| NCBI Synonym Full Names: | interleukin 33 |
| NCBI Official Symbol: | Il33�� |
| NCBI Official Synonym Symbols: | RGD1311155�� |
| NCBI Protein Information: | interleukin-33; IL-33 |
| UniProt Protein Name: | Interleukin-33 |
| UniProt Synonym Protein Names: | |
| Protein Family: | Interleukin |
| UniProt Gene Name: | Il33�� |
| UniProt Entry Name: | IL33_RAT |
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