Cytokines Recombinant Proteins

Rat IL 3 Recombinant Protein (RPPB0500)

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SKU:
RPPB0500
Product Type:
Recombinant Protein
Species:
Rat
Uniprot:
P04823
Research Area:
Cytokines

Description

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Product Name:Rat IL 3 Recombinant Protein
Product Code:RPPB0500
Size:20µg
Species:Rat
Target:IL 3
Synonyms:MCGF (Mast cell growth factor), Multi-CSF, HCGF, P-cell stimulation factor, IL-3, MGC79398, MGC79399.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation:Interleukin-3 Rat was lyophilized from a 0.2�m filtered concentrated solution in PBS, pH 7.4.
Solubility:It is recommended to reconstitute the lyophilized Interleukin 3 in sterile 18M?-cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions.
Stability:Lyophilized Interleukin-3 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution IL3 should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
Purity:Greater than 97.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE.
Amino Acid Sequence:MISDRGSDAH HLLRTLDCRT IALEILVKLP YPQVSGLNNS DDKANLRNST LRRVNLDEFL KSQEEFDSQD TTDIKSKLQK LKCCIPAAAS DSVLPGVYNK DLDDFKKKLR FYVIHLKDLQ PVSVSRPPQP TSSSDNFRPM TVEC
Biological Activity:The ED50 as determined by the dose-dependent stimulation of the proliferation of thymidine uptake by murine MC-9 cells is < 10 ng/ml, corresponding to a specific activity of >1.0 x 105 units/mg.

Interleukin-3 is a pleiotropic cytokine produced primarily by activated T cells. IL-3 is thought to function via specific cell surface receptors to stimulate the proliferation, differentiation and survival of haematopoietic cell lines. IL-3 has also been shown to affect the functional activity of a variety of other cell types including mast cells, eosinophils, megakaryocytes and basophils.

Interleukin-3 Rat Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 144 amino acids and having a molecular mass of 16.3kDa. The IL-3 is purified by proprietary chromatographic techniques.

UniProt Protein Function:Function: Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages.
NCBI Summary:cytokine that functions as a multi-lineage haemopoietic growth regulator [RGD, Feb 2006]
UniProt Code:P04823
NCBI GenInfo Identifier:124334
NCBI Gene ID:24495
NCBI Accession:P04823.1
UniProt Secondary Accession:P04823,P70513,
UniProt Related Accession:P04823
Molecular Weight:18,631 Da
NCBI Full Name:Interleukin-3
NCBI Synonym Full Names:interleukin 3
NCBI Official Symbol:Il3��
NCBI Protein Information:interleukin-3; IL-3; MCGF; mast cell growth factor; P-cell-stimulating factor; hematopoietic growth factor; multipotential colony-stimulating factor
UniProt Protein Name:Interleukin-3
UniProt Synonym Protein Names:Hematopoietic growth factor; Mast cell growth factor; MCGF; Multipotential colony-stimulating factor; P-cell-stimulating factor
Protein Family:Interleukin
UniProt Gene Name:Il3��
UniProt Entry Name:IL3_RAT
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