Cytokines Recombinant Proteins

Rat IL 2 Recombinant Protein (RPPB0483)

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RPPB0483

Description

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Product Name:Rat IL 2 Recombinant Protein
Product Code:RPPB0483
Size:20µg
Species:Rat
Target:IL 2
Synonyms:T-cell growth factor (TCGF), Aldesleukin, Lymphokine, IL-2.
Source:Escherichia Coli
Physical Appearance:Sterile filtered colorless solution.
Formulation:The IL-2 solution contains 0.2�m filtered solution in 20mM PB pH3.5 and 30% Glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks.Store, frozen at -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 97.0% as determined by SDS-PAGE and HPLC.
Amino Acid Sequence:APTSSPAKET QQHLEQLLLD LQVLLRGIDN YKNLKLPMML TFKFYLPKQA TELKHLQCLE NELGALQRVL DLTQSKSFHL EDAGNFISNI RVTVVKLKGS ENKFECQFDD EPATVVEFLR RWIAICQSII STMTQ
Biological Activity:The ED50 as determined by the dose-dependant stimulation of murine CTLL-2 cells is less than 0.2ng/ml, corresponding to a Specific Activity of 5,000,000IU/mg.

IL2 is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli.

Interleukin-2 Rat Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 135 amino acids and having a molecular mass of 16kDa.The IL-2 is purified by proprietary chromatographic techniques.

UniProt Protein Function:Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.
NCBI Summary:cytokine produced by T-cells in response to antigen or mitogen stimulation [RGD, Feb 2006]
UniProt Code:P17108
NCBI GenInfo Identifier:124328
NCBI Gene ID:116562
NCBI Accession:P17108.1
UniProt Related Accession:P17108
Molecular Weight:17,633 Da
NCBI Full Name:Interleukin-2
NCBI Synonym Full Names:interleukin 2
NCBI Official Symbol:Il2��
NCBI Protein Information:interleukin-2; IL-2; TCGF; T-cell growth factor
UniProt Protein Name:Interleukin-2
UniProt Synonym Protein Names:T-cell growth factor; TCGF
Protein Family:Interleukin
UniProt Gene Name:Il2��
UniProt Entry Name:IL2_RAT
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Additional Information

Product Type:
Recombinant Protein
Species:
Rat
Uniprot:
P17108
Research Area:
Cytokines
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