Cytokines Recombinant Proteins
Rat IL 17 Recombinant Protein (RPPB0614)
- SKU:
- RPPB0614
- Product Type:
- Recombinant Protein
- Species:
- Rat
- Uniprot:
- Q61453
- Research Area:
- Cytokines
Description
| Product Name: | Rat IL 17 Recombinant Protein |
| Product Code: | RPPB0614 |
| Size: | 25µg |
| Species: | Rat |
| Target: | IL 17 |
| Synonyms: | CTLA-8, IL-17, IL-17A, Cytotoxic T-lymphocyte-associated antigen 8, Interleukin-17A. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | Lyophilized from a concentrated (1mg/ml) solution containing 10mM NaCitrate, pH-3.0. |
| Solubility: | It is recommended to reconstitute the lyophilized Interleukin Rat 17A in sterile 18M?-cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions. |
| Stability: | Lyophilized Interleukin Rat 17A although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Rat IL17 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles. |
| Purity: | Greater than 97.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE. |
| Amino Acid Sequence: | MAVLIPQSSV CPNAEANNFL QNVKVNLKVL NSLSSKASSR RPSDYLNRST SPWTLSRNED PDRYPSVIWE AQCRHQRCVN AEGKLDHHMN SVLIQQEILV LKREPEKCPF TFRVEKMLVG VGCTCVSSIV RHAS |
| Biological Activity: | The ED50 as determined by dose-dependent induction of IL-6 by mouse NIH 3T3 fibroblasts is 0.44-0.66ng/ml. |
IL17 is a proinflammatory cytokine produced by activated T cells. IL-17 regulates the activities of NF-kappaB and mitogen-activated protein kinases. Interleukin-17 can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of IL-17 are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.
Interleukin-17A Rat Recombinant produced in E.Coli is a homodimeric, non-glycosylated polypeptide chain having a molecular mass of 30 kDa. The IL-17A Rat is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | Ligand for IL17RA and IL17RC. The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC. Involved in inducing stromal cells to produce proinflammatory and hematopoietic cytokines. |
| NCBI Summary: | cytokine; may be involved in immune system function or to cell death and cell survival [RGD, Feb 2006] |
| UniProt Code: | Q61453 |
| NCBI GenInfo Identifier: | 2498483 |
| NCBI Gene ID: | 301289 |
| NCBI Accession: | Q61453.1 |
| UniProt Related Accession: | Q61453 |
| Molecular Weight: | 16,877 Da |
| NCBI Full Name: | Interleukin-17A |
| NCBI Synonym Full Names: | interleukin 17A |
| NCBI Official Symbol: | Il17a�� |
| NCBI Official Synonym Symbols: | Il17; IL-17; CTLA-8; IL-17A�� |
| NCBI Protein Information: | interleukin-17A |
| UniProt Protein Name: | Interleukin-17A |
| UniProt Synonym Protein Names: | Cytotoxic T-lymphocyte-associated antigen 8; CTLA-8 |
| UniProt Gene Name: | Il17a�� |
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