Cytokines Recombinant Proteins
Rat IL-1 Alpha Recombinant Protein (RPPB0452)
- SKU:
- RPPB0452
- Product Type:
- Recombinant Protein
- Species:
- Rat
- Uniprot:
- P16598
- Research Area:
- Cytokines
Description
| Product Name: | Rat IL-1 Alpha Recombinant Protein |
| Product Code: | RPPB0452 |
| Size: | 10µg |
| Species: | Rat |
| Target: | IL-1 Alpha |
| Synonyms: | Interleukin-1 alpha, IL-1 alpha. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | IL1A protein solution (1mg/ml) contains 10% glycerol & Phosphate Buffered Saline (pH 7.4). |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSSAPHSFQ NNLRYKLIRI VKQEFIMNDS LNQNIYVDMDRIHLKAASLN DLQLEVKFDM YAYSSGGDDSKYPVTLKVSN TQLFVSAQGE DKPVLLKEIPETPKLITGSE TDLIFFWEKI NSKNYFTSAA FPELLIATKE QSQVHLARGL PSMIDFQIS |
| Biological Activity: | The ED50 that was measured in a cell proliferation assay using D10.G4.1 mouse helper T cell is <20 pg/ml. |
IL-1 alpha is produced by activated macrophages.IL-1 alpha stimulates thymocyte proliferation by inducing il-2 release, b-cell maturation and proliferation, and fibroblast growth factor activity. IL1A proteins take part in the inflammatory response, being identified as endogenous pyrogens, and stimulate the release of prostaglandin and collagenase from synovial cells.
IL1A Rat Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 179 amino acids (115-270 a.a) and having a molecular mass of 20.2kDa.IL1A is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. |
| NCBI Summary: | proinflammatory cytokine [RGD, Feb 2006] |
| UniProt Code: | P16598 |
| NCBI GenInfo Identifier: | 124301 |
| NCBI Gene ID: | 24493 |
| NCBI Accession: | P16598.1 |
| UniProt Secondary Accession: | P16598,Q546R9, |
| UniProt Related Accession: | P16598 |
| Molecular Weight: | 30,856 Da |
| NCBI Full Name: | Interleukin-1 alpha |
| NCBI Synonym Full Names: | interleukin 1 alpha |
| NCBI Official Symbol: | Il1a�� |
| NCBI Official Synonym Symbols: | IL-1 alpha�� |
| NCBI Protein Information: | interleukin-1 alpha |
| UniProt Protein Name: | Interleukin-1 alpha |
| Protein Family: | Interleukin |
| UniProt Gene Name: | Il1a�� |
| UniProt Entry Name: | IL1A_RAT |
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