Cytokines Recombinant Proteins
Rat IL 1 alpha Recombinant Protein (RPPB0451)
- SKU:
- RPPB0451
- Product Type:
- Recombinant Protein
- Species:
- Rat
- Uniprot:
- P16598
- Research Area:
- Cytokines
Description
| Product Name: | Rat IL 1 alpha Recombinant Protein |
| Product Code: | RPPB0451 |
| Size: | 20µg |
| Species: | Rat |
| Target: | IL 1 alpha |
| Synonyms: | Interleukin-1 alpha, IL-1 alpha. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | IL 1 alpha protein solution (1mg/ml) containing PhosphateBuffered Saline (pH 7.4) and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4weeks. Store, frozen at -20°C for longer periods of time.�For long term storage it is recommended to add a carrierprotein (0.1% HSA or BSA).�Avoid multiple freeze-thaw cycles. |
| Purity: | Greaterthan 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSSAPHSFQ NNLRYKLIRI VKQEFIMNDS LNQNIYVDMD RIHLKAASLNDLQLEVKFDM YAYSSGGDDS KYPVTLKVSN TQLFVSAQGE DKPVLLKEIP ETPKLITGSE TDLIFFWEKINSKNYFTSAA FPELLIATKE QSQVHLARGL PSMIDFQIS |
| Biological Activity: | The biological activity was Rat IL1 alpha was measured in a cell proliferation assay using D10.G4.1 mouse helper T cell. The ED50 for this effect is less or equal to 20 pg/ml. |
IL-1 alpha is produced by activated macrophages, stimulates thymocyte proliferation by inducing il-2 release, b-cell maturation and proliferation, and fibroblast growth factor activity. IL1A proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.
IL 1 alpha Rat Recombinant produced in E.Coli is asingle, non-glycosylated polypeptide chain containing 179 amino acids (115-270 a.a)and having a molecular mass of 20.2kDa.IL 1 alpha is fused to a 23 amino acid His-tag atN-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. |
| NCBI Summary: | proinflammatory cytokine [RGD, Feb 2006] |
| UniProt Code: | P16598 |
| NCBI GenInfo Identifier: | 124301 |
| NCBI Gene ID: | 24493 |
| NCBI Accession: | P16598.1 |
| UniProt Secondary Accession: | P16598,Q546R9, |
| UniProt Related Accession: | P16598 |
| Molecular Weight: | 30,856 Da |
| NCBI Full Name: | Interleukin-1 alpha |
| NCBI Synonym Full Names: | interleukin 1 alpha |
| NCBI Official Symbol: | Il1a�� |
| NCBI Official Synonym Symbols: | IL-1 alpha�� |
| NCBI Protein Information: | interleukin-1 alpha |
| UniProt Protein Name: | Interleukin-1 alpha |
| Protein Family: | Interleukin |
| UniProt Gene Name: | Il1a�� |
| UniProt Entry Name: | IL1A_RAT |
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