Cytokines Recombinant Proteins
Rat IL 1 alpha Recombinant Protein (RPPB0450)
- SKU:
- RPPB0450
- Product Type:
- Recombinant Protein
- Species:
- Rat
- Uniprot:
- P16598
- Research Area:
- Cytokines
Description
| Product Name: | Rat IL 1 alpha Recombinant Protein |
| Product Code: | RPPB0450 |
| Size: | 10µg |
| Species: | Rat |
| Target: | IL 1 alpha |
| Synonyms: | Hematopoietin-1, Lymphocyte-activating factor (LAF), Endogenous Pyrogen (EP), Leukocyte Endogenous Mediator (LEM), Mononuclear Cell Factor (MCF), IL-1 alpha,IL1, IL-1A, IL1F1. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | The protein was lyophilized from a concentrated (1mg/ml) sterile solution containing 50mM Tris-HCl, pH=8. |
| Solubility: | It is recommended to reconstitute the lyophilized Interleukin 1a in sterile 18M?-cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions. |
| Stability: | Lyophilized Interleukin-1a although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution IL1A should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles. |
| Purity: | Greater than 98.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE. |
| Amino Acid Sequence: | The sequence of the first five N-terminal amino acids was determined and was found to be Ala-Pro-His-Ser-Phe |
| Biological Activity: | The ED50 as determined by the dose-dependant stimulation of murine D10S cells is < 0.005 ng/ml, corresponding to a Specific Activity of 200,000,000IU/mg. |
Interleukin-1 alpha is a proinflammatory cytokine produced by a wide variety of cell types, including macrophages, osteoblasts, monocytes and hepatocytes. Circulating levels of are normally low and only rise after stimulation by agents such as those produced byinflammation, infection or microbial endotoxins. IL-1 alpha possesses a wide variety of biological activities and exerts its effects by binding to specific cell surface receptors.
Interleukin-1A Rat Recombinant produced in E.Coli is single, a non-glycosylated, Polypeptide chain containing 155 amino acids and having a molecular mass of 17703 Dalton. The IL-1A is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. |
| NCBI Summary: | proinflammatory cytokine [RGD, Feb 2006] |
| UniProt Code: | P16598 |
| NCBI GenInfo Identifier: | 124301 |
| NCBI Gene ID: | 24493 |
| NCBI Accession: | P16598.1 |
| UniProt Secondary Accession: | P16598,Q546R9, |
| UniProt Related Accession: | P16598 |
| Molecular Weight: | 30,856 Da |
| NCBI Full Name: | Interleukin-1 alpha |
| NCBI Synonym Full Names: | interleukin 1 alpha |
| NCBI Official Symbol: | Il1a�� |
| NCBI Official Synonym Symbols: | IL-1 alpha�� |
| NCBI Protein Information: | interleukin-1 alpha |
| UniProt Protein Name: | Interleukin-1 alpha |
| Protein Family: | Interleukin |
| UniProt Gene Name: | Il1a�� |
| UniProt Entry Name: | IL1A_RAT |
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