Epigenetics & Nuclear Signaling Recombinant Proteins
Rat HER2/ErbB2 Recombinant Protein (RPES2568)
- SKU:
- RPES2568
- Product Type:
- Recombinant Protein
- Species:
- Rat
- Research Area:
- Epigenetics & Nuclear Signaling
Description
Rat HER2/ErbB2 Recombinant Protein
ERBB2 belongs to the protein kinase superfamily, Tyr protein kinase family and EGF receptor subfamily. It contains a protein kinase domain. ERBB2 is widely expressed in epithelial cells, and amplification and/or overexpression of ErbB2 has been reported associated with malignancy and a poor prognosis in numerous carcinomas, including breast, prostate and ovarian cancers. Rat ERBB2 is an essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. ErbB2 mediates signalling pathways which involve mitogen-activated protein kinase and phosphatidylinositol-3 kinase, this receptor plays a key role in development, cell proliferation and differentiation.
| Product Name: | Rat HER2/ErbB2 Recombinant Protein (RPES2568) |
| Product Code: | RPES2568 |
| Size: | 10µg |
| Species: | Rat |
| Expressed Host: | E.coli |
| Synonyms: | Receptor tyrosine-protein kinase erbB-2, Epidermal growth factor receptor-related protein, Proto-oncogene Neu, Proto-oncogene c-ErbB-2, p185erbB2, p185neu, CD340, ERBB2,ENV,ENVW,ERVWE1,HER-2,HER-2/neu,HER2,HERV-7q,HERV-W-ENV,HERV7Q,HERVW,HERVWENV,MLN 19,MLN19 |
| Accession: | P06494 |
| Sequence: | Ala67-Val323 |
| Fusion tag: | C-6His |
| Endotoxin: | <1.0 EU per µg as determined by LAL test. |
| Protein Construction: | Recombinant Rat Receptor tyrosine-protein kinase ErbB-2 is produced by our E.coli expression system and the target gene encoding Ala67-Val323 is expressed with a 6His tag at the C-terminus. |
| Purity: | > 95 % as determined by SDS-PAGE |
| Mol Mass: | 29.3 kDa |
| AP Mol Mass: | 32 kDa |
| Formulation: | Lyophilized from a 0.2 µm filtered solution of 20mM Tris,150mM NaCl, 4M Urea, pH 8.0. |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
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