Chemokines Recombinant Proteins

Rat GRO g/CINC-2a Recombinant Protein (RPPB1155)

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SKU:
RPPB1155
Product Type:
Recombinant Protein
Species:
Rat
Uniprot:
Q10746
Research Area:
Chemokines

Description

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Product Name:Rat GRO g/CINC-2a Recombinant Protein
Product Code:RPPB1155
Size:10µg
Species:Rat
Target:GRO g/CINC-2a
Synonyms:Cytokine-induced neutrophil chemoattractant 2, CINC2, CINC-2, Macrophage inflammatory protein 2-alpha.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation:The Rat CXCL3 lyophilized from a 0.2�m filtered concentrated solution in 1�PBS, pH 7.4.
Solubility:It is recommended to reconstitute the lyophilized GRO-gamma in sterile 18Mcm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions.
Stability:Lyophilized GRO-gamma although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CXCL3 should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
Purity:Greater than 98.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE.
Amino Acid Sequence:RELRCQCLKT LPRVDFENIQ SLTVTPPGPH CTQTEVIATL KDGQEVCLNP QAPRLQKIIQ KLLKSDKSS
Biological Activity:Determined by its ability to chemoattract 293 transfected CXCR2 cells using a concentration range of 10-100 ng/ml, corresponding to a specific activity of 10,000-100,000 units/mg.

Chemokine (C-X-C motif) ligand 3 (CXCL3) is a small cytokine belonging to the CXC chemokine family that is also known as GRO3 oncogene (GRO3), GRO protein gamma (GROg) and macrophage inflammatory protein-2-beta (MIP2b). CXCL3 controls migration and adhesion of monocytes and mediates it effects on its target cell by interacting with a cell surface chemokine receptor called CXCR2. The gene for CXCL3 is located on chromosome 4 in a cluster of other CXC chemokines.

GRO-g Rat Recombinant produced in E.Coli is a single,non-glycosylated, polypeptide chain containing 69 amino acids and having a molecular mass of 7.8kDa. The CXCL3 is purified by proprietary chromatographic techniques.

UniProt Protein Function:CXCL1: Has chemotactic activity for neutrophils. May play a role in inflammation and exerts its effects on endothelial cells in an autocrine fashion. In vitro, the processed forms GRO- alpha(4-73), GRO-alpha(5-73) and GRO-alpha(6-73) show a 30-fold higher chemotactic activity. Belongs to the intercrine alpha (chemokine CxC) family.Protein type: Motility/polarity/chemotaxis; Secreted, signal peptide; SecretedCellular Component: cytosol; extracellular spaceMolecular Function: chemokine activity; CXCR chemokine receptor bindingBiological Process: elevation of cytosolic calcium ion concentration; G-protein coupled receptor protein signaling pathway; immune response; inflammatory response; neutrophil chemotaxis; regulation of cell proliferation; response to lipopolysaccharide
UniProt Protein Details:
NCBI Summary:acts as a chemoattractant for neutrophils; involved in the inflammatory response [RGD, Feb 2006]
UniProt Code:Q10746
NCBI GenInfo Identifier:215273965
NCBI Gene ID:171551
NCBI Accession:Q10746.2
UniProt Secondary Accession:Q10746,Q10747, Q5CZ55, Q9EP62
UniProt Related Accession:Q10746
Molecular Weight:10,989 Da
NCBI Full Name:C-X-C motif chemokine 3
NCBI Synonym Full Names:chemokine (C-X-C motif) ligand 3
NCBI Official Symbol:Cxcl3��
NCBI Official Synonym Symbols:Cinc2; Cinc-2; Gm1960��
NCBI Protein Information:C-X-C motif chemokine 3
UniProt Protein Name:C-X-C motif chemokine 3
UniProt Synonym Protein Names:Cytokine-induced neutrophil chemoattractant 2; CINC-2; Macrophage inflammatory protein 2-alpha/beta; MIP2-alpha/beta
Protein Family:C-X-C motif chemokine
UniProt Gene Name:Cxcl3��
UniProt Entry Name:CXCL3_RAT
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