Chemokines Recombinant Proteins

Rat GRO b Recombinant Protein (RPPB1149)

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SKU:
RPPB1149
Product Type:
Recombinant Protein
Species:
Rat
Uniprot:
P30348
Research Area:
Chemokines

Description

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Product Name:Rat GRO b Recombinant Protein
Product Code:RPPB1149
Size:20µg
Species:Rat
Target:GRO b
Synonyms:Macrophage inflammatory protein 2-alpha, MIP2-alpha, CXCL2, Growth- regulated protein beta, Gro-beta, chemokine (C-X-C motif) ligand 2, GRO2, GROb, MIP2, MIP2A, SCYB2, MGSA-b, MIP-2a, CINC-2a, MGSA beta, CINC-3.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation:Lyophilized from a 0.2�m filtered concentrated solution in PBS, pH 7.4.
Solubility:It is recommended to reconstitute the lyophilized GRO-beta Rat in sterile 18M?-cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions.
Stability:Lyophilized GRO-b although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CXCL2 should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
Purity:Greater than 99.0% as determined by SDS-PAGE.
Amino Acid Sequence:VVVASELRCQ CLTTLPRVDF KNIQSLTVTP PGPHCAQTEV IATLKDGHEV CLNPEAPLVQ RIVQKILNKG KAN
Biological Activity:The biological activity was determined by its ability to chemoattract total human neutrophils using a concentration range of 1.0-10.0 ng/ml, corresponding to a specific activity of 100,000-1,000,000 units/mg.

Chemokine (C-X-C motif) ligand 2 (CXCL2) is a small cytokine belonging to the CXC chemokine family that is also called macrophage inflammatory protein 2-alpha (MIP2-alpha), Growth-regulated protein beta (Gro-beta) and Gro oncogene-2 (Gro-2). CXCL2 is 90% identical in amino acid sequence as a related chemokine, CXCL1. This chemokine is secreted by monocytes and macrophages and is chemotactic for polymorphonuclear leukocytes and hematopoietic stem cells. The gene for CXCL2 is located on human chromosome 4 in a cluster of other CXC chemokines. CXCL2 mobilizes cells by interacting with a cell surface chemokine receptor called CXCR2.

GRO-Beta Rat Recombinant also called Rat MIP-2 produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 73 amino acids and having a molecular mass of 7923 Dalton. The GRO-b is purified by proprietary chromatographic techniques.

UniProt Protein Function:CXCL3: Ligand for CXCR2. Has chemotactic activity for neutrophils. May play a role in inflammation and exert its effects on endothelial cells in an autocrine fashion. In vitro, the processed form GRO-gamma(5-73) shows a fivefold higher chemotactic activity for neutrophilic granulocytes. Belongs to the intercrine alpha (chemokine CxC) family.
UniProt Protein Details:

Protein type:Secreted; Secreted, signal peptide; Motility/polarity/chemotaxis

Cellular Component: cytosol; extracellular space

Molecular Function:chemokine activity; CXCR chemokine receptor binding

Biological Process: elevation of cytosolic calcium ion concentration; G-protein coupled receptor protein signaling pathway; immune response; inflammatory response; leukocyte chemotaxis; neutrophil chemotaxis; regulation of cell proliferation; response to amphetamine; response to estradiol stimulus; response to gamma radiation; response to glucocorticoid stimulus; response to heat; response to molecule of bacterial origin; wound healing

NCBI Summary:chemokine involved in the pulmonary inflammatory response [RGD, Feb 2006]
UniProt Code:P30348
NCBI GenInfo Identifier:266536
NCBI Gene ID:114105
NCBI Accession:P30348.1
UniProt Secondary Accession:P30348,Q5WA60,
UniProt Related Accession:P30348
Molecular Weight:10,783 Da
NCBI Full Name:C-X-C motif chemokine 2
NCBI Synonym Full Names:C-X-C motif chemokine ligand 2
NCBI Official Symbol:Cxcl2��
NCBI Official Synonym Symbols:Mip-2; Scyb2��
NCBI Protein Information:C-X-C motif chemokine 2
UniProt Protein Name:C-X-C motif chemokine 2
UniProt Synonym Protein Names:Cytokine-induced neutrophil chemoattractant 3; CINC-3; Macrophage inflammatory protein 2; MIP2
Protein Family:C-X-C motif chemokine
UniProt Gene Name:Cxcl2��
UniProt Entry Name:CXCL2_RAT
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