Neurotrophins Recombinant Proteins

Rat GFRA1 Recombinant Protein (RPPB0299)

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SKU:
RPPB0299
Product Type:
Recombinant Protein
Species:
Rat
Uniprot:
Q62997
Research Area:
Neurotrophins

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Rat GFRA1 Recombinant Protein
Product Code:RPPB0299
Size:5µg
Species:Rat
Target:GFRA1
Synonyms:GDNF family receptor alpha-1, GDNF receptor alpha-1, GDNFR-alpha-1, GFR-alpha-1, RET ligand 1, TGF-beta-related neurotrophic factor receptor 1, Gfra1, Gdnfra, Retl1, Trnr1.
Source:Sf9 Insect cells
Physical Appearance:Sterile Filtered colorless solution.
Formulation:GFRA1 protein solution (0.25mg/ml) contains Phosphate Buffered Saline (pH 7.4) and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85% as determined by SDS-PAGE.
Amino Acid Sequence:DRLDCVKASD QCLKEQSCST KYRTLRQCVA GKETNFSLTS GLEAKDECRS AMEALKQKSL YNCRCKRGMK KEKNCLRIYW SMYQSLQGND LLEDSPYEPV NSRLSDIFRA VPFISDVFQQ VEHISKGNNC LDAAKACNLD DTCKKYRSAY ITPCTTSMSN EVCNRRKCHK ALRQFFDKVP AKHSYGMLFC SCRDIACTER RRQTIVPVCS YEERERPNCL SLQDSCKTNY ICRSRLADFF TNCQPESRSV SNCLKENYAD CLLAYSGLIG TVMTPNYVDS SSLSVAPWCD CSNSGNDLED CLKFLNFFKD NTCLKNAIQA FGNGSDVTMW QPAPPVQTTT ATTTTAFRVK NKPLGPAGSE NEIPTHVLPP CANLQAQKLK SNVSGSTHLC LSDSDFGKDG LAGASSLEPK SCDKTHTCPP CPAPELLGGP SVFLFPPKPK DTLMISRTPE VTCVVVDVSH EDPEVKFNWY VDGVEVHNAK TKPREEQYNS TYRVVSVLTV LHQDWLNGKE YKCKVSNKAL PAPIEKTISK AKGQPREPQV YTLPPSRDEL TKNQVSLTCL VKGFYPSDIA VEWESNGQPE NNYKTTPPVL DSDGSFFLYS KLTVDKSRWQ QGNVFSCSVM HEALHNHYTQ KSLSLSPGKH HHHHH

GDNF family receptor alpha-1 (GFRA1) belongs to the GDNF receptor family. GFRA1 is a glycosyl-phosphatidylinositol(GPI)-linked cell surface receptor for both Glial cell line-derived growth factor (GDNF), neurturin (NTN), and mediates activation of the RET tyrosine kinase receptor. The GFRA1 protein is a potent survival factor for central and peripheral neurons, and is vital for the development of kidneys and the enteric nervous system.

GFRA1 Rat Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 645 amino acids (25-430a.a.) and having a molecular mass of 72.3kDa (Molecular size on SDS-PAGE will appear at approximately 70-100kDa). GFRA1 is expressed with a 239 amino acid hIgG-His tag at C-Terminus and purified by proprietary chromatographic techniques.

UniProt Protein Function:Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor.
NCBI Summary:binds glial cell line-derived neurotrophic factor (GDNF) and mediates Ret protein-tyrosine kinase receptor phosphorylation and activation [RGD, Feb 2006]
UniProt Code:Q62997
NCBI GenInfo Identifier:2494710
NCBI Gene ID:25454
NCBI Accession:Q62997.1
UniProt Related Accession:Q62997
Molecular Weight:
NCBI Full Name:GDNF family receptor alpha-1
NCBI Synonym Full Names:GDNF family receptor alpha 1
NCBI Official Symbol:Gfra1��
NCBI Protein Information:GDNF family receptor alpha-1
UniProt Protein Name:GDNF family receptor alpha-1
UniProt Synonym Protein Names:RET ligand 1; TGF-beta-related neurotrophic factor receptor 1
Protein Family:GDNF family receptor
UniProt Gene Name:Gfra1��
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