Neurotrophins Recombinant Proteins
Rat GDNF Recombinant Protein (RPPB0297)
- SKU:
- RPPB0297
- Product Type:
- Recombinant Protein
- Species:
- Rat
- Uniprot:
- Q07731
- Research Area:
- Neurotrophins
Description
| Product Name: | Rat GDNF Recombinant Protein |
| Product Code: | RPPB0297 |
| Size: | 10µg |
| Species: | Rat |
| Target: | GDNF |
| Synonyms: | ATF1, ATF2, HFB1-GDNF, GDNF. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | GDNF was lyophilized from a sterile solution containing 1xPBS, pH 7.4. |
| Solubility: | It is recommended to reconstitute the lyophilized Glial Derived Neurotrophic Factor in sterile 18M?-cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions. |
| Stability: | Lyophilized Glial-derived Neurotrophic Factor although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution GDNF should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles. |
| Purity: | Greater than 98.0% as determined by HPLC analysis and by SDS-PAGE. |
| Amino Acid Sequence: | SPDKQAALP RRENRNRQAAA ASPENSRGKG RRGQRGKNRG CVLTAIHLNV TDLGLGYETK EELIFRYCSG SCESAETMYD KILKNLSRSR RLTSDKVGQA CCRPVAFDDD LSFLDDNLVY HILRKHSAKR CGCI� |
| Biological Activity: | Recombinant rat GDNF has full biological activity when compared to standards. The ED50, determined by a cell proliferation assay using rat C6 cells, is less than 0.2ng/ml corresponding to a specific activity of more than 5,000,000IU/mg. |
GDNF promotes the survival and differentiation of neurons in culture, and is able to prevent apoptosis of motor neurons induced by axotomy. The encoded protein is processed to a mature secreted form that exists as a homodimer. The mature form of the protein is a ligand for the product of the RET (rearranged during transfection) protooncogene. In addition to the transcript encoding GDNF, two additional alternative transcripts encoding distinct proteins, referred to as astrocyte-derived trophic factors, have also been described. Mutations in this gene may be associated with Hirschsprung disease.GDNF enhances survival and morphological differentiation of neurons and increases their high-affinity uptake.
Glial derived Neurotrophic Factor Rat Recombinant produced in E.Coli is a homodimer, non-glycosylated, polypeptide chain containing 2 x 134 amino acids and having a total molecular mass of 29.8 kDa.�
| UniProt Protein Function: | Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake. May also modulate local neuronal effects in distal regions of the motor neuron. |
| NCBI Summary: | neurotrophic factor specific for midbrain dopamine neurons; binds to GDNFR-alpha and mediates activation of the Ret protein tyrosine kinase receptor [RGD, Feb 2006] |
| UniProt Code: | Q07731 |
| NCBI GenInfo Identifier: | 729568 |
| NCBI Gene ID: | 25453 |
| NCBI Accession: | Q07731.1 |
| UniProt Secondary Accession: | Q07731,Q63214, Q64062, Q64063, Q8R485, Q9QX94, Q9QX95 Q9QXJ7, Q9QXJ8, Q9QXJ9, |
| UniProt Related Accession: | Q07731 |
| Molecular Weight: | 23,551 Da |
| NCBI Full Name: | Glial cell line-derived neurotrophic factor |
| NCBI Synonym Full Names: | glial cell derived neurotrophic factor |
| NCBI Official Symbol: | Gdnf�� |
| NCBI Official Synonym Symbols: | gndf�� |
| NCBI Protein Information: | glial cell line-derived neurotrophic factor; ATF; astrocyte-derived trophic factor; Glial cell line derived neutrophic factor; glial cell line derived neurotrophic factor |
| UniProt Protein Name: | Glial cell line-derived neurotrophic factor |
| UniProt Synonym Protein Names: | Astrocyte-derived trophic factor; ATF |
| Protein Family: | GDNF family receptor |
| UniProt Gene Name: | Gdnf�� |
| UniProt Entry Name: | GDNF_RAT |
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