Growth Factors & Cytokines Recombinant Proteins

Rat FGF 9 Recombinant Protein (RPPB0223)

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SKU:
RPPB0223
Product Type:
Recombinant Protein
Species:
Rat
Uniprot:
P36364
Research Area:
Growth Factors & Cytokines

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Rat FGF 9 Recombinant Protein
Product Code:RPPB0223
Size:10µg
Species:Rat
Target:FGF 9
Synonyms:GAF (Glia-activating factor), HBGF-9, MGC119914, MGC119915, FGF-9.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation:The FGF-9 was lyophilized from a concentrated (1mg/ml) sterile solution containing 10mM NaP, pH-7.5 &, 75mM Ammonium Sulfate.
Solubility:It is recommended to reconstitute the lyophilized Rat FGF-9 in sterile 18M?-cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions.
Stability:Lyophilized Rat Fibroblast Growth Factor-9 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution FGF9 Rat Recombinant should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
Purity:Greater than 95.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE.
Amino Acid Sequence:MPLGEVGSYFG VQDAVPFGNV PVLPVDSPVL LNDHLGQSEA GGLPRGPAVT DLDHLKGILR RRQLYCRTGF HLEIFPNGTI QGTRKDHSRF GILEFISIAV GLVSIRGVDS GLYLGMNEKG ELYGSEKLTQ ECVFREQFEE NWYNTYSSNL YKHVDTGRRY YVALNKDGTP REGTRTKRHQ KFTHFLPRPV DPDKVPELYK DILSQS
Biological Activity:The ED50, calculated by the dose-dependant proliferation of BAF3 cells expressing FGF receptors (measured by 3H-thymidine uptake) is <0.5 ng/ml, corresponding to a specific activity of�2,000,000 Units/mg.

Rat and mouse FGF-9 show a very high homology to human FGF-9. The transcripts for FGF-9 have been found in brain and in kidney tissue. Fibroblast Growth Factor-9 is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF9 was isolated as a secreted factor that exhibits a growth-stimulating effect on cultured glial cells. In nervous system, this protein is produced mainly by neurons and may be important for glial cell development. Expression of the mouse homolog of this gene was found to be dependent on Sonic hedgehog (Shh) signaling. Mice lacking the homolog gene displayed a male-to-female sex reversal phenotype, which suggested a role in testicular embryogenesis Fibroblast Growth Factor 9 may have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors.

Rat FGF9 Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 207 amino acids and having a molecular mass of 23.3kDa.The FGF-9 Mouse Recombinant is purified by proprietary chromatographic techniques.

UniProt Protein Function:FGF9: Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. May have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors. Defects in FGF9 are the cause of multiple synostoses syndrome type 3 (SYNS3). Multiple synostoses syndrome is an autosomal dominant condition characterized by progressive joint fusions of the fingers, wrists, ankles and cervical spine, characteristic facies and progressive conductive deafness. Belongs to the heparin-binding growth factors family.
UniProt Protein Details:

Protein type:Cytokine

Cellular Component: extracellular space; cell; cytoplasm; basement membrane; intracellular

Molecular Function:heparin binding; growth factor activity; fibroblast growth factor receptor binding

Biological Process: negative regulation of Wnt receptor signaling pathway; embryonic skeletal development; negative regulation of transcription from RNA polymerase II promoter; positive regulation of vascular endothelial growth factor receptor signaling pathway; positive regulation of activin receptor signaling pathway; substantia nigra development; positive regulation of MAPKKK cascade; cell-cell signaling; protein import into nucleus; male sex determination; positive regulation of cell proliferation; positive regulation of mesenchymal cell proliferation; chondrocyte differentiation; positive regulation of smoothened signaling pathway; angiogenesis; embryonic gut development; regulation of timing of cell differentiation; positive regulation of cardiac muscle cell proliferation; embryonic limb morphogenesis; inner ear morphogenesis; fibroblast growth factor receptor signaling pathway; male gonad development; osteoblast differentiation; positive regulation of cell division; positive regulation of epithelial cell proliferation; lung development

NCBI Summary:human homolog is a heparin-binding growth factor [RGD, Feb 2006]
UniProt Code:P36364
NCBI GenInfo Identifier:25742766
NCBI Gene ID:25444
NCBI Accession:NP_037084.1
UniProt Related Accession:P36364
Molecular Weight:23.3 kDa
NCBI Full Name:fibroblast growth factor 9
NCBI Synonym Full Names:fibroblast growth factor 9
NCBI Official Symbol:Fgf9��
NCBI Protein Information:fibroblast growth factor 9
UniProt Protein Name:Fibroblast growth factor 9
UniProt Synonym Protein Names:Glia-activating factor; GAF; HBGF-9
Protein Family:Fibroblast growth factor
UniProt Gene Name:Fgf9��
UniProt Entry Name:FGF9_RAT
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