Chemokines Recombinant Proteins

Rat Eotaxin Recombinant Protein (RPPB1125)

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SKU:
RPPB1125
Product Type:
Recombinant Protein
Species:
Rat
Uniprot:
P97545
Research Area:
Chemokines

Description

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Product Name:Rat Eotaxin Recombinant Protein
Product Code:RPPB1125
Size:20µg
Species:Rat
Target:Eotaxin
Synonyms:Small inducible cytokine A11, CCL11, Eosinophil chemotactic protein, chemokine (C-C motif) ligand 11, SCYA11.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation:Filtered (0.2�m) and lyophilized from a concentrated (1mg/ml) solution in in 1�PBS, pH7.4.
Solubility:It is recommended to reconstitute the lyophilized Eotaxin in sterile 18M-cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions.
Stability:Lyophilized Eotaxin although stable at room temperature for 3 weeks, should be stored desiccated below -18C. Upon reconstitution CCL11 should be stored at 4C between 2-7 days and for future use below -18C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
Purity:Greater than 97.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE.
Amino Acid Sequence:HPGSIPTSCC FTMTSKKIPN TLLKSYKRIT NNRCTLKAIV FKTKLGKEICADPKKKWVQD ATKHLDQKLQ TPKP
Biological Activity:Determined by its ability to chemoattract purified blood eosinophils using a concentration range of 0.1-1.0 ug/ml, corresponding to a Specific Activity of 10-100IU/mg.

Chemokine (C-C motif) ligand 11 (CCL11) is a small cytokine belonging to the CC chemokine family that is also known as eotaxin. CCL11 selectively recruits eosinophils by inducing their chemotaxis, and therefore, is implicated in allergic responses. The effects of CCL11 are mediated by its binding to a G-protein-linked receptor known as a chemokine receptor. Chemokine receptors for which CCL11 is a ligand include CCR2, CCR3 and CCR5. The gene for human CCL11 (scya11) is encoded on three exons and is located on chromosome 17.

Eotaxin Rat Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 74 amino acids and having a molecular mass of 8.4kDa. The CCL11 is purified by proprietary chromatographic techniques.

UniProt Protein Function:In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions.
NCBI Summary:mouse homolog is an eosinophil chemoattractant [RGD, Feb 2006]
UniProt Code:P97545
NCBI GenInfo Identifier:11276089
NCBI Gene ID:29397
NCBI Accession:NP_062078.1
UniProt Related Accession:P97545
Molecular Weight:
NCBI Full Name:eotaxin
NCBI Synonym Full Names:C-C motif chemokine ligand 11
NCBI Official Symbol:Ccl11��
NCBI Official Synonym Symbols:Scya11��
NCBI Protein Information:eotaxin
UniProt Protein Name:Eotaxin
UniProt Synonym Protein Names:C-C motif chemokine 11; Eosinophil chemotactic protein; Small-inducible cytokine A11
UniProt Gene Name:Ccl11��
UniProt Entry Name:CCL11_RAT
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