Rat EGFR/ErbB1 Recombinant Protein (RPES5227)
- SKU:
- RPES5227
- Product Type:
- Recombinant Protein
- Species:
- Rat
Description
Rat EGFR/ErbB1 Recombinant Protein
As a member of the epidermal growth factor receptor (EGFR) family, EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-α, betacellulin, etc. EGFR protein plays a crucial role in signaling pathway in the regulation of cell proliferation, survival and differentiation. Binding of a ligand induces EGFR protein homo- or heterodimerization, the subsequent tyrosine autophosphorylation and initiates various down stream pathways (MAPK, PI3K/PKB and STAT). In addition, EGFR signaling also has been shown to exert action on carcinogenesis and disease progression, and thus EGFR protein is proposed as a target for cancer therapy currently.Immune Checkpoint Immunotherapy Cancer Immunotherapy Targeted Therapy
| Product Name: | Rat EGFR/ErbB1 Recombinant Protein (RPES5227) |
| Product Code: | RPES5227 |
| Size: | 50µg |
| Species: | Rat |
| Expressed Host: | HEK293 Cells |
| Synonyms: | EGFR |
| Accession: | E7CXR8 |
| Sequence: | Met1-Ser646 |
| Fusion tag: | C-His |
| Activity: | 1. Measured by its ability to bind recombinant human EGF-Fc in a functional ELISA.2. Measured by its ability to bind recombinant mouse EGF-Fc in a functional ELISA. |
| Protein Construction: | A DNA sequence encoding the rat EGFR (E7CXR8) (Met1-Ser646) was expressed, fused with a polyhistidine tag at the C-terminus. |
| Purity: | > 98 % as determined by SDS-PAGE |
| Mol Mass: | 70.7 kDa |
| AP Mol Mass: | 93-110 kDa |
| Formulation: | Lyophilized from sterile PBS, pH 7.4 |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
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