Enzymes Recombinant Proteins

Rat Cyclophilin A Recombinant Protein (RPPB1533)

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SKU:
RPPB1533
Product Type:
Recombinant Protein
Species:
Rat
Uniprot:
P10111
Research Area:
Enzymes

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Rat Cyclophilin A Recombinant Protein
Product Code:RPPB1533
Size:10µg
Species:Rat
Target:Cyclophilin A
Synonyms:Peptidyl-prolyl cis-trans isomerase A, EC:5.2.1.8, PPIase A, Cyclophilin A, Cyclosporin A-binding protein, Rotamase A, p1B15, p31, Ppia.
Source:Escherichia Coli
Physical Appearance:Filtered White lyophilized (freeze-dried) powder.
Formulation:Cyclophilin-A was filtered (0.4�m) and lyophilized from 0.5mg/ml solution in phosphate buffered saline and 5%(w/v) trehalose.
Solubility:It is recommended to add deionized water to prepare a working stock solution of approximately 0.5mg/ml and let the lyophilized pellet dissolve completely. Cyclophilin-A is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture.
Stability:Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:MKHHHHHHASVNPTVFFDIT ADGEPLGRVC FELFADKVPK TAENFRALST GEKGFGYKGS SFHRIIPGFM CQGGDFTRHN GTGGKSIYGE KFEDENFILK HTGPGILSMA NAGPNTNGSQ FFICTAKTEW LDGKHVVFGK VKEGMSIVEA MERFGSRNGK TSKKITISDC GQL

PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. Cyclophilin-A is a cyclosporin binding-protein and may play a role in cyclosporin A-mediated immunosuppression. Cyclophilin-A can also interact with several HIV proteins, including p55 gag, Vpr, and capsid protein, and has been shown to be necessary for the formation of infectious HIV virions. Multiple pseudogenes that map to different chromosomes have been reported.

Cyclophilin-A Rat Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain (Val2-Leu164) containing 173 amino acids including a 10 aa His tag at N-terminus. The total calculated molecular mass is 19kDa.

UniProt Protein Function:PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
NCBI Summary:may play a role in protein folding or intracellular protein transport [RGD, Feb 2006]
UniProt Code:P10111
NCBI GenInfo Identifier:8394009
NCBI Gene ID:25518
NCBI Accession:NP_058797.1
UniProt Related Accession:P10111
Molecular Weight:
NCBI Full Name:peptidyl-prolyl cis-trans isomerase A
NCBI Synonym Full Names:peptidylprolyl isomerase A
NCBI Official Symbol:Ppia��
NCBI Official Synonym Symbols:CYCA; CyP-A��
NCBI Protein Information:peptidyl-prolyl cis-trans isomerase A
UniProt Protein Name:Peptidyl-prolyl cis-trans isomerase A
UniProt Synonym Protein Names:Cyclophilin A; Cyclosporin A-binding protein; Rotamase A; p1B15; p31
Protein Family:Cypemycin
UniProt Gene Name:Ppia��
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system_update_altDatasheetHuman Cyclophilin A Recombinant Protein Peptidyl-prolyl cis-trans isomerase A; also known as PPIase A; Rotamase A; Cyclophilin A; Cyclosporin A-binding protein; PPIA a