Rat CRP Recombinant Protein (RPPB3264)
- SKU:
- RPPB3264
Description
| Product Name: | Rat CRP Recombinant Protein |
| Product Code: | RPPB3264 |
| Size: | 10µg |
| Species: | Rat |
| Target: | CRP |
| Synonyms: | Ptx1, C-reactive protein, Pentraxin1, C-Reactive Protein Pentraxin-Related. |
| Source: | Sf9 Insect cells |
| Physical Appearance: | Sterilefiltered colorless solution. |
| Formulation: | CRP protein solution (0.5mg/ml) contains PhosphateBuffered Saline (pH 7.4) and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks.Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greaterthan 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | HEDMSKQAFV FPGVSATAYV SLEAESKKPL EAFTVCLYAHADVSRSFSIF SYATKTSFNE ILLFWTRGQG FSIAVGGPEI LFSASEIPEV PTHICATWES ATGIVELWLDGKPRVRKSLQ KGYIVGTNAS IILGQEQDSY GGGFDANQSL VGDIGDVNMW DFVLSPEQIN AVYVGRVFSPNVLNWRALKY ETHGDVFIKP QLWPLTDCCE SHHHHHH |
CRP is an acute phase protein that correlates with inflammatory disease and is synthesized by hepatocytes during the acute phase response by certain cytokines (IL-1 and TNF Alpha and Beta). CRP levels increase dramatically (up to 1,000 fold) and serve as a useful marker of inflammation in such conditions as bacterial infection, rheumatoid arthritis, viral infections, transplantation rejection, meningitis, myocardial infarction, septicemia, osteomyelitis and others. CRP is also highly correlated to Serum Amyloid A levels.
CRP produced in Sf9 Insect cells is a single,glycosylated polypeptide chain containing 217 amino acids (20-230 a.a.) andhaving a molecular mass of 24.1kDa. (Molecular size on SDS-PAGE will appear atapproximately 28-40 kDa).CRP is expressed with a 6 amino acid His tag atC-Terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. |
| NCBI Summary: | glycoprotein of the acute phase response [RGD, Feb 2006] |
| UniProt Code: | P48199 |
| NCBI GenInfo Identifier: | 1345834 |
| NCBI Gene ID: | 25419 |
| NCBI Accession: | P48199.1 |
| UniProt Secondary Accession: | P48199,Q5BK94, |
| UniProt Related Accession: | P48199 |
| Molecular Weight: | 25,468 Da |
| NCBI Full Name: | C-reactive protein |
| NCBI Synonym Full Names: | C-reactive protein, pentraxin-related |
| NCBI Official Symbol: | Crp�� |
| NCBI Official Synonym Symbols: | Aa1249; Ac1262; Ab1-341; Ab2-196; Ac1-114; Ac2-069; Ba2-693�� |
| NCBI Protein Information: | C-reactive protein; C-reactive protein, petaxin related; C-reactive protein member of the pentraxin family; C-reactive protein, member of the pentraxin family |
| UniProt Protein Name: | C-reactive protein |
| Protein Family: | Cryparin |
| UniProt Gene Name: | Crp�� |
| UniProt Entry Name: | CRP_RAT |
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