Rat CD8a Monoclonal Antibody (AF488 Conjugated) [OX-8](AGEL1272)

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SKU:
AGEL1272
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Rat
Applications:
FC

Description

Antibody Name:Rat CD8a Monoclonal Antibody (AF488 Conjugated)
Antibody Code:AGEL1272
Size:50µg
Clone:OX-8
Synonyms:T-cell surface glycoprotein CD8 alpha chain,CD8A,T-lymphocyte differentiation antigen T8/Leu-2,MAL
Host Species:Mouse
Species Reactivity:Rat
Applications:FC
Concentration:1mg/mL
Isotype:IgG2a,k
Conjugation:AF488
Applications:FC
Recommended Dilution:Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 10e6 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Storage Buffer:PBS with 0.05% Proclin300, 1% BSA
Storage:Store at 2-8°C and protected from prolonged exposure to light. Do not freeze.
Gene ID:24930
Uniprot:P07725
Background:CD8a is a 32 kD glycoprotein also known as T8, Lyt2, Ly-2, and CD8α. CD8a is a member of the immunoglobulin superfamily expressed on most thymocytes, subset of mature T cells, most NK cells, macrophages, and some activated CD4+ T cells (not resting). CD8a forms heterodimers with the CD8β chain (CD8b) on the surface of most thymocytes, while mature peripheral T lymphocytes express almost exclusively the CD8 αβ heterodimer. Intestinal intraepithelial lymphocytes express CD8a without CD8b. CD8 is an antigen co-receptor on T cells that interacts with MHC class I on antigen-presenting cells or epithelial cells. CD8 participates in T cell activation through its association with the T cell receptor complex and protein tyrosine kinase lck (p56lck).
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