Cytokines Recombinant Proteins

Rat BD 1 Recombinant Protein (RPPB0070)

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SKU:
RPPB0070
Product Type:
Recombinant Protein
Species:
Rat
Uniprot:
O89117
Research Area:
Cytokines

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Rat BD 1 Recombinant Protein
Product Code:RPPB0070
Size:20µg
Species:Rat
Target:BD 1
Synonyms:Beta-defensin 1, BD-1, rBD-1, Defensin beta 1, Defb1.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation:BD-1 protein was lyophilized from a 0.2�m filtered concentrated solution in PBS, pH 7.4.
Solubility:It is recommended to reconstitute the lyophilized BD-1 in sterile 18M-cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions.
Stability:Lyophilized BD-1 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution BD-1 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
Purity:Greater than 95.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE.
Amino Acid Sequence:DQYRCLQNGG FCLRSSCPSH TKLQGTCKPD KPNCCRS
Biological Activity:Measured by its ability to chemoattract CD34+ dendritic cells using a concentration range of 0.1-1.0 ug/ml.

The Defensin family are highly similar in their protein sequence and are microbicidal & cytotoxic peptides made by neutrophils. Beta Defensin-1 is an antimicrobial peptide having the resistance of epithelial surfaces to microbial colonization. Beta Defensin-1 has close proximity to Defensin Alpha-1 and has been implicated in the pathogenesis of cystic fibrosis.Skin of patients having atopic dermatitis patients and mycosis fungoides (non-lesional and lesional) show lower human Beta Defensin-1 mRNA expression and higher human Beta Defensin-2 and human Beta Defensin-3 mRNA expression. Beta Defensin is highly expressed by epithelial cells. Beta-defensin 1 may play a role in the pathogenesis of severe sepsis.

BD-1 Rat Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 37 amino acids and having a molecular mass of 4.1kDa.The BD-1 is purified by proprietary chromatographic techniques.

UniProt Protein Function:defensin, beta 1: Has bactericidal activity. Belongs to the beta-defensin family.Protein type: Motility/polarity/chemotaxis; Secreted; Secreted, signal peptideChromosomal Location of Human Ortholog: 16q12.5Cellular Component: extracellular space; extrinsic component of membrane; intracellularMolecular Function: CCR6 chemokine receptor binding; identical protein bindingBiological Process: acute inflammatory response; antibacterial humoral response; cAMP-mediated signaling; defense response to bacterium; defense response to Gram-negative bacterium; defense response to Gram-positive bacterium; innate immune response; innate immune response in mucosa; response to bacterium; response to testosterone stimulus
UniProt Protein Details:
NCBI Summary:cationic peptides with broad-spectrum antimicrobial activity; may mediate mucosal defenses of several organs [RGD, Feb 2006]
UniProt Code:O89117
NCBI GenInfo Identifier:13929150
NCBI Gene ID:83687
NCBI Accession:NP_113998.1
UniProt Secondary Accession:O89117
UniProt Related Accession:O89117
Molecular Weight:
NCBI Full Name:beta-defensin 1
NCBI Synonym Full Names:defensin beta 1
NCBI Official Symbol:Defb1��
NCBI Official Synonym Symbols:CDK4��
NCBI Protein Information:beta-defensin 1
UniProt Protein Name:Beta-defensin 1
UniProt Synonym Protein Names:Defensin, beta 1
Protein Family:Beta-defensin
UniProt Gene Name:Defb1��
UniProt Entry Name:
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