Rat AIF-M1 Recombinant Protein (His tag)

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SKU:
RPES5886
Product Type:
Recombinant Protein
Species:
Rat

Description

Product Name:Rat AIF-M1 Recombinant Protein (His tag)
Product Code:RPES5886
Size:20µg
Species:Rat
Expression Host:E.coli
Synonyms:AIFM1, Apoptosis inducing factor 1, mitochondrial, Apoptosis inducing factor, CMTX4, COWCK, COXPD6, Harlequin, mitochondrial, PDCD 8, Programmed cell death 8, Striatal apoptosis inducing factor
Mol Mass:16.39 kDa
AP Mol Mass:18 kDa
Tag:N-His
Purity:> 95 % as determined by reducing SDS-PAGE.
Endotoxin Level:Please contact us for more information.
Bio Activity:Testing in progress
Sequence:Arg 150-Val 299
Accession:Q9JM53
Storage:Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Shipping:This product is provided as lyophilized powder which is shipped with ice packs.
Formulation:Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual.
Reconstitution:Please refer to the printed manual for detailed information.
Background:Probable oxidoreductase that has a dual role in controlling cellular life and death; during apoptosis, it is translocated from the mitochondria to the nucleus to function as a proapoptotic factor in a caspase-independent pathway, while in normal mitochondria, it functions as an antiapoptotic factor via its oxidoreductase activity. The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e., caspase-independent fragmentation of chromosomal DNA. Interacts with EIF3G,and thereby inhibits the EIF3 machinery and protein synthesis, and activates casapse-7 to amplify apoptosis. Plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells. Binds to DNA in a sequence-independent manner.
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