RASSF7 Antibody (PACO58468)
- SKU:
- PACO58468
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | RASSF7 Antibody (PACO58468) |
| Antibody SKU: | PACO58468 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IF:1:50-1:200 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Recombinant Human Ras association domain-containing protein 7 protein (300-368AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot. Positive WB detected in: Mouse liver tissue. All lanes: RASSF7 antibody at 4.3µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 40, 37, 35 kDa. Observed band size: 40 kDa. |
 | Immunofluorescence staining of HepG2 cells with PACO58468 at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
| Background: | Negatively regulates stress-induced JNK activation and apoptosis by promoting MAP2K7 phosphorylation and inhibiting its ability to activate JNK. Following prolonged stress, anti-apoptotic effect stops because of degradation of RASSF7 protein via the ubiquitin-proteasome pathway. Required for the activation of AURKB and chromosomal congression during mitosis where it stimulates microtubule polymerization. |
| Synonyms: | Ras association domain-containing protein 7 (HRAS1-related cluster protein 1), RASSF7, C11orf13 HRC1 |
| UniProt Protein Function: | HRC1: 2 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: 11p15.5Molecular Function: protein binding |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q02833 |
| NCBI GenInfo Identifier: | 18202480 |
| NCBI Gene ID: | 8045 |
| NCBI Accession: | Q02833.1 |
| UniProt Secondary Accession: | Q02833,Q3KP41, Q3KP42, G5E9N9 |
| UniProt Related Accession: | Q02833 |
| Molecular Weight: | 34,660 Da |
| NCBI Full Name: | Ras association domain-containing protein 7 |
| NCBI Synonym Full Names: | Ras association domain family member 7 |
| NCBI Official Symbol: | RASSF7 |
| NCBI Official Synonym Symbols: | HRC1; HRAS1; C11orf13 |
| NCBI Protein Information: | ras association domain-containing protein 7 |
| UniProt Protein Name: | Ras association domain-containing protein 7 |
| UniProt Synonym Protein Names: | HRAS1-related cluster protein 1 |
| Protein Family: | Ras association domain-containing protein |
| UniProt Gene Name: | RASSF7 |
| UniProt Entry Name: | RASF7_HUMAN |
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