RASGEF1A Antibody (PACO16945)
- SKU:
- PACO16945
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | RASGEF1A Antibody (PACO16945) |
| Antibody SKU: | PACO16945 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:1000-1:2000, IHC:1:10-1:50 |
| Species Reactivity: | Human |
| Immunogen: | Fusion protein of human RASGEF1A |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO16945(RASGEF1A Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200). |
| Background: | RASGEF1A (RasGEF domain family, member 1A) is a 481 amino acid, guanine-nucleotide exchange factor (GEF) for H-Ras, K-Ras, and N-Ras. RASGEF1A may also play a role in cell migration. RASFEG1A is highly expressed in spinal chord and brain and contains one N-terminal Ras-GEF domain and one Ras-GEF domain. The gene that encodes RASGEF1A maps to human chromosome 10, which contains over 800 genes and 135 million nucleotides, making up nearly 4.5% of the human genome. PTEN is an important tumor suppressor gene located on chromosome 10 and, when defective, causes a genetic predisposition to cancer development known as Cowden syndrome. |
| Synonyms: | RasGEF domain family, member 1A |
| UniProt Protein Function: | Guanine nucleotide exchange factor (GEF) with specificity for RAP2A, KRAS, HRAS, and NRAS (in vitro). Plays a role in cell migration. |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q8N9B8 |
| NCBI GenInfo Identifier: | 544583543 |
| NCBI Gene ID: | 221002 |
| NCBI Accession: | NP_001269791.1 |
| UniProt Secondary Accession: | Q8N9B8,Q8TBF1 |
| UniProt Related Accession: | Q8N9B8 |
| Molecular Weight: | 52 |
| NCBI Full Name: | ras-GEF domain-containing family member 1A isoform 1 |
| NCBI Synonym Full Names: | RasGEF domain family member 1A |
| NCBI Official Symbol: | RASGEF1A |
| NCBI Official Synonym Symbols: | CG4853 |
| NCBI Protein Information: | ras-GEF domain-containing family member 1A |
| UniProt Protein Name: | Ras-GEF domain-containing family member 1A |
| UniProt Synonym Protein Names: | |
| Protein Family: | |
| UniProt Gene Name: | RASGEF1A |
| UniProt Entry Name: |
| Antibodies |
| RASGEF1A Antibody (PACO11731) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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