RASA3 Antibody (PACO20322)
- SKU:
- PACO20322
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | RASA3 Antibody (PACO20322) |
| Antibody SKU: | PACO20322 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:25-1:100 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Synthetic peptide of human RASA3 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO20322(RASA3 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | The protein encoded by this gene is member of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. This family member is an inositol 1,3,4,5-tetrakisphosphate-binding protein, like the closely related RAS p21 protein activator 2. |
| Synonyms: | RAS p21 protein activator 3 |
| UniProt Protein Function: | RASA3: Inhibitory regulator of the Ras-cyclic AMP pathway. Binds inositol tetrakisphosphate (IP4) with high affinity. Might be a specific IP4 receptor. |
| UniProt Protein Details: | Protein type:GAPs; GAPs, Ras Chromosomal Location of Human Ortholog: 13q34 Cellular Component: cytoplasm; cytosol Molecular Function:calcium-release channel activity Biological Process: MAPKKK cascade; negative regulation of Ras protein signal transduction; signal transduction |
| NCBI Summary: | This gene encodes a protein that binds inositol 1,3,4,5-tetrakisphosphate and stimulates the GTPase activity of Ras p21. This protein functions as a negative regulator of the Ras signalling pathway. It is localized to the cell membrane via a pleckstrin homology (PH) domain in the C-terminal region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016] |
| UniProt Code: | Q14644 |
| NCBI GenInfo Identifier: | 206729910 |
| NCBI Gene ID: | 22821 |
| NCBI Accession: | Q14644.3 |
| UniProt Secondary Accession: | Q14644,Q8IUY2, A6NL15, F8W6X8, |
| UniProt Related Accession: | Q14644 |
| Molecular Weight: | 92,228 Da |
| NCBI Full Name: | Ras GTPase-activating protein 3 |
| NCBI Synonym Full Names: | RAS p21 protein activator 3 |
| NCBI Official Symbol: | RASA3 |
| NCBI Official Synonym Symbols: | GAPIII; GAP1IP4BP |
| NCBI Protein Information: | ras GTPase-activating protein 3 |
| UniProt Protein Name: | Ras GTPase-activating protein 3 |
| UniProt Synonym Protein Names: | GAP1(IP4BP); Ins P4-binding protein |
| Protein Family: | Ras GTPase-activating protein |
| UniProt Gene Name: | RASA3 |
| UniProt Entry Name: | RASA3_HUMAN |
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