RAPGEF5 Antibody (PACO38086)
- SKU:
- PACO38086
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | RAPGEF5 Antibody (PACO38086) |
| Antibody SKU: | PACO38086 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Rap guanine nucleotide exchange factor 5 protein (201-444AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human testis tissue using PACO38086 at dilution of 1:100. |
 | Immunohistochemistry of paraffin-embedded human spleen tissue using PACO38086 at dilution of 1:100. |
| Background: | Guanine nucleotide exchange factor (GEF) for RAP1A, RAP2A and MRAS/M-Ras-GTP. Its association with MRAS inhibits Rap1 activation. |
| Synonyms: | Rap guanine nucleotide exchange factor 5 (Guanine nucleotide exchange factor for Rap1) (M-Ras-regulated Rap GEF) (MR-GEF) (Related to Epac) (Repac), RAPGEF5, GFR KIAA0277 MRGEF |
| UniProt Protein Function: | RAPGEF5: Guanine nucleotide exchange factor (GEF) for RAP1A, RAP2A and MRAS/M-Ras-GTP. Its association with MRAS inhibits Rap1 activation. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:GAPs; GAPs, Ras Chromosomal Location of Human Ortholog: 7p15.3 Cellular Component: nucleus Molecular Function:GTP-dependent protein binding; Rap guanyl-nucleotide exchange factor activity; Ras guanyl-nucleotide exchange factor activity |
| NCBI Summary: | Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF5, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q92565 |
| NCBI GenInfo Identifier: | 32171396 |
| NCBI Gene ID: | 9771 |
| NCBI Accession: | Q92565.1 |
| UniProt Secondary Accession: | Q92565,Q8IXU5, A4D140, |
| UniProt Related Accession: | Q92565 |
| Molecular Weight: | 52,083 Da |
| NCBI Full Name: | Rap guanine nucleotide exchange factor 5 |
| NCBI Synonym Full Names: | Rap guanine nucleotide exchange factor 5 |
| NCBI Official Symbol: | RAPGEF5 |
| NCBI Official Synonym Symbols: | GFR; REPAC; MR-GEF |
| NCBI Protein Information: | rap guanine nucleotide exchange factor 5 |
| UniProt Protein Name: | Rap guanine nucleotide exchange factor 5 |
| UniProt Synonym Protein Names: | Guanine nucleotide exchange factor for Rap1; M-Ras-regulated Rap GEF; MR-GEF; Related to Epac; Repac |
| Protein Family: | Rap guanine nucleotide exchange factor |
| UniProt Gene Name: | RAPGEF5 |
| UniProt Entry Name: | RPGF5_HUMAN |
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