Rad23B Polyclonal Antibody
- SKU:
- CAB21586
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- Applications:
- IHC
- Applications:
- IF
Description
| Product Name: | Rad23B Polyclonal Antibody |
| Product Code: | CAB21586 |
| Reactivity: | Human, Mouse |
| Applications: | Western blotting, Immunohistochemistry, Immunofluorescence |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Reactivity: | Human, Mouse |
| Tested Applications: | WB, IHC-P, IF/ICC, ELISA |
| Key Applications: | Western blotting, Immunohistochemistry, Immunofluorescence |
| Recommended Dilution: | WB 1:500-1:2000, IHC-P 1:50-1:200, IF/ICC 1:50-1:200 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Cellular Location: | Cytoplasm, Nucleus |
The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in the nucleotide excision repair (NER). This protein was found to be a component of the protein complex that specifically complements the NER defect of xeroderma pigmentosum group C (XP-c) cell extracts in vitro. This protein was also shown to interact with, and elevate the nucleotide excision activity of 3-methyladenine-DNA glycosylase (MPG), which suggested a role in DNA damage recognition in base excision repair. This protein contains an N-terminal ubiquitin-like domain, which was reported to interact with 26S proteasome, and thus this protein may be involved in the ubiquitin mediated proteolytic pathway in cells. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 100-200 of human Rad23B (NP_002865.1). |
| Sequence: | TSSTT TTVAQ APTPV PALAP TSTPA SITPA SATAS SEPAP ASAAK QEKPA EKPAE TPVAT SPTAT DSTSG DSSRS NLFED ATSAL VTGQS YENMV TEIMS M |
| Synonyms: | P58, HR23B, HHR23B |
| Calculated MW: | 43kDa |
| Observed MW: | Refer to figures |
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