R3HCC1L Antibody (PACO19704)
- SKU:
- PACO19704
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | R3HCC1L Antibody (PACO19704) |
| Antibody SKU: | PACO19704 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:50-1:200 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Synthetic peptide of human R3HCC1L |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using PACO19704(R3HCC1L Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200). |
 | The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO19704(R3HCC1L Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | C10orf28 (chromosome 10 open reading frame 28), also known as GIDRP88 (growth inhibition and differentiation-related protein 88) or putative mitochondrial space protein 32.1, is a 792 amino acid, protein that exists as three alternatively spliced isoforms. The gene encoding C10orf28 maps to human chromosome 10, which spans nearly 135 million base pairs, makes up approximately 4.5% of total DNA in cells and encodes nearly 1,200 genes. Several protein-coding genes, including those that encode for chemokines, cadherins, excision repair proteins, early growth response factors (Egrs) and fibroblast growth receptors (FGFRs), are located on chromosome 10. Defects in some of the genes that map to chromosome 10 are associated with Charcot-Marie Tooth disease, Jackson-Weiss syndrome, Usher syndrome, nonsyndromatic deafness, Wolmans syndrome, Cowden syndrome, multiple endocrine neoplasia type 2 and porphyria. |
| Synonyms: | R3H domain and coiled-coil containing 1-like |
| UniProt Protein Function: | This potassium channel may be involved in the regulation of insulin secretion by glucose and/or neurotransmitters acting through G-protein-coupled receptors. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q7Z5L2 |
| NCBI GenInfo Identifier: | 375298727 |
| NCBI Gene ID: | 27291 |
| NCBI Accession: | NP_001243548 |
| UniProt Secondary Accession: | Q7Z5L2 |
| UniProt Related Accession: | Q7Z5L2 |
| Molecular Weight: | 87kDa |
| NCBI Full Name: | coiled-coil domain-containing protein R3HCC1L isoform 1 |
| NCBI Synonym Full Names: | R3H domain and coiled-coil containing 1 like |
| NCBI Official Symbol: | R3HCC1L |
| NCBI Official Synonym Symbols: | PSORT; GIDRP86; GIDRP88; C10orf28 |
| NCBI Protein Information: | coiled-coil domain-containing protein R3HCC1L |
| UniProt Protein Name: | G protein-activated inward rectifier potassium channel 2 |
| UniProt Synonym Protein Names: | BIR1; Inward rectifier K(+) channel Kir3.2; KATP-2; Potassium channel, inwardly rectifying subfamily J member 6 |
| Protein Family: | G protein-activated inward rectifier potassium channel |
| UniProt Gene Name: | KCNJ6 |
| UniProt Entry Name: |
| Antibodies |
| R3HCC1L Antibody (PACO03892) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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