PYHIN1 Antibody (PACO36818)
- SKU:
- PACO36818
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | PYHIN1 Antibody (PACO36818) |
| Antibody SKU: | PACO36818 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Recombinant Human Pyrin and HIN domain-containing protein 1 protein (1-245AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot. All lanes: PYHIN1 antibody at 6µg/ml + Mouse small intestine tissue. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 56, 55, 52, 51, 27, 26 kDa. Observed band size: 56, 22, 84 kDa. |
| Background: | Major mediator of the tumor suppressor activity of IFN in breast cancer cells. Promotes ubiquitination and subsequent degradation of MDM2, which leads to p53/TP53 stabilization. Promotes ubiquitination and subsequent degradation of HDAC1, which in turn enhances maspin expression, and impairs invasive activity of cancer cells. |
| Synonyms: | Pyrin and HIN domain-containing protein 1 (Interferon-inducible protein X), PYHIN1, IFIX |
| UniProt Protein Function: | Major mediator of the tumor suppressor activity of IFN in breast cancer cells. Promotes ubiquitination and subsequent degradation of MDM2, which leads to p53/TP53 stabilization. Promotes ubiquitination and subsequent degradation of HDAC1, which in turn enhances maspin expression, and impairs invasive activity of cancer cells. |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene belongs to the HIN-200 family of interferon-inducible proteins that share a 200-amino acid signature motif at their C-termini. HIN200 proteins are primarily nuclear and are involved in transcriptional regulation of genes important for cell cycle control, differentiation, and apoptosis. Downregulation of this gene is associated with breast cancer. This protein acts as a tumor suppressor by promoting ubiquitination and subsequent degradation of MDM2, which leads to stabilization of p53/TP53. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011] |
| UniProt Code: | Q6K0P9 |
| NCBI GenInfo Identifier: | 39540514 |
| NCBI Gene ID: | 149628 |
| NCBI Accession: | NP_689714.2 |
| UniProt Secondary Accession: | Q6K0P9,Q5T3W6, Q6K0P6, Q6K0P7, Q6K0P8, Q8WW65 |
| UniProt Related Accession: | Q6K0P9 |
| Molecular Weight: | |
| NCBI Full Name: | pyrin and HIN domain-containing protein 1 isoform alpha 1 |
| NCBI Synonym Full Names: | pyrin and HIN domain family member 1 |
| NCBI Official Symbol: | PYHIN1 |
| NCBI Official Synonym Symbols: | IFIX |
| NCBI Protein Information: | pyrin and HIN domain-containing protein 1 |
| UniProt Protein Name: | Pyrin and HIN domain-containing protein 1 |
| UniProt Synonym Protein Names: | Interferon-inducible protein X |
| Protein Family: | Pyrin and HIN domain-containing protein |
| UniProt Gene Name: | PYHIN1 |
| UniProt Entry Name: | IFIX_HUMAN |
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