Purified Mouse TCR gamma/delta Monoclonal Antibody [UC7-13D5](AGEL1556)

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SKU:
AGEL1556
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Applications:
FC

Description

Antibody Name:Purified Mouse TCR γ/δ Monoclonal Antibody
Antibody Code:AGEL1556
Size:100µg
Clone:UC7-13D5
Synonyms:TCR-γ/δ, γ/δ TCR
Host Species:Armenian Hamster
Species Reactivity:Mouse
Applications:FC, IP
Concentration:1mg/mL
Isotype:IgG2a,k
Conjugation:Unconjugated
Applications:FC, IP
Recommended Dilution:Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 10e6 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Storage Buffer:PBS with 0.05% Proclin300
Storage:Store at 2-8°C. Do not freeze.
Gene ID:110066,110067
Background:T cell receptor (TCR) is a heterodimer consisting of an α and a β chain (TCR α/β) or a γ and a δ chain (TCR γ/δ). TCR γ/δ belongs to the immunoglobulin superfamily, involved in the recognition of certain bacterial and tumor antigens bound to MHC class I. The TCR γ/δ associates with CD3 and is expressed on a T cell subset found in the thymus, the intestinal epithelium, and the peripheral lymphoid tissues and peritoneum. Most γ/δ T cells are CD4-/CD8-, some are CD8+. T cells expressing the TCR γ/δ have been shown to play a role in oral tolerance, tumor-associated tolerance, and autoimmune disease. It has been reported that γ/δ T cells also play a principal role in antigen presentation. Immobilized UC7-13D5 antibody has been reported to activate TCR-γ/δ-bearing T cells in vitro, and to deplete peripheral TCR-γ/δ-bearing T cells in vivo.
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