Purified Human CD274/PD-L1 Monoclonal Antibody [29E.2A3](AGEL1646)

Name: Purified Human CD274/PD-L1 Monoclonal Antibody [29E.2A3](AGEL1646)
SKU: AGEL1646
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OverviewAntibody Name:AF/LE Purified Human CD274/PD-L1 Monoclonal AntibodyAntibody Code:AGEL1645Size:500µgClone:29E.2A3<

OverviewAntibody Name:Human CD274/PD-L1 Monoclonal Antibody (FITC Conjugated)Antibody Code:AGEL1648Size:50 TestsClone:29E.2A3<

OverviewAntibody Name:Human CD274/PD-L1 Monoclonal Antibody (PE Conjugated)Antibody Code:AGEL1649Size:50 TestsClone:29E.2A3

OverviewAntibody Name:Human CD274/PD-L1 Monoclonal Antibody (APC Conjugated)Antibody Code:AGEL1650Size:50 TestsClone:29E.2A3

OverviewAntibody Name:Human CD274/PD-L1 Monoclonal Antibody (Biotin Conjugated)Antibody Code:AGEL1647Size:100µgClone:29E.2A3<

OverviewProduct Name:PE/Cyanine5 Anti-Human CD274/PD-L1 Antibody [29E.2A3]Product Code:AGEL2261Clone No:29E.2A3Synonyms:B7-H1, PD

OverviewProduct Name:PE/Cyanine7 Anti-Human CD274/PD-L1 Antibody [29E.2A3]Product Code:AGEL2262Clone No:29E.2A3Synonyms:B7-H1, PD

OverviewProduct Name:PerCP/Cyanine5.5 Anti-Human CD274/PD-L1 Antibody [29E.2A3]Product Code:AGEL2263Clone No:29E.2A3Synonyms:B7-H

OverviewProduct Name:CD274/PD-L1 Monoclonal AntibodyProduct Code:CAB24571Reactivity:MouseApplications:Flow Cytometry

Concentration:	1mg/mL
Isotype:	IgG2a,k
Conjugation:	Unconjugated
Applications:	FC, IHC
Recommended Dilution:	Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 10e6 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Storage Buffer:	PBS with 0.05% Proclin300
Storage:	Store at 2-8°C. Do not freeze.

Gene ID:	29126
Uniprot:	Q9NZQ7
Background:	CD274, also known as PD-L1 and B7-H1, is type I transmembrane glycoprotein that serves as a ligand for CD279 (PD-1). This interaction is believed to regulate the balance between the stimulatory and inhibitory signals needed for responses to microbes and maintenance of self-tolerance. CD274 is involved in the costimulation of T cell proliferation and IL-10 and IFN-γ production in an IL-2-dependent and CD279-independent manner. Conflicting data has shown that CD274 can inhibit T cell proliferation and cytokine production, and alternatively, enhance T cell activation. Other studies suggest that CD274 may signal bidirectionally, raising interesting implications for its expression in a wide variety of cell types, including T and B cells, antigen-presenting cells, and nonhematopoietic cells.

Antibody Name:	Purified Human CD274/PD-L1 Monoclonal Antibody
Antibody Code:	AGEL1646
Size:	100µg
Clone:	29E.2A3
Synonyms:	B7-H1, PD-L1,Programmed cell death ligand 1,B7 homolog 1,B7-H, B7H1, PDL1, PDCD1L1, PDCD1LG1
Host Species:	Mouse
Species Reactivity:	Human
Applications:	FC, IHC