Purified Anti-Human/Mouse KLRG-1 Antibody [2F1]

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SKU:
AGEL3513
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Applications:
FCM
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Syrian Hamster
Isotype:
Syrian Hamster IgG
Clone:
2F1
Conjugation:
Unconjugated

Description

Product Name:Purified Anti-Human/Mouse KLRG-1 Antibody [2F1]
Product Code:AGEL3513
Size:25ug, 100ug
Clone No:2F1
Synonyms:MAFA, 2F1-Ag
Reactivity:Human,Mouse
Host Species:Syrian Hamster
Applications:FCM
Isotype:Syrian Hamster IgG
Conjugation:Unconjugated
Applications:FCM
Recommended Dilution:Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 106 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer.
Storage:Keep as concentrated solution. Store at 2-8°C. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Shipping:Biological ice pack at 4°C
Form:Liquid
Gene ID:1021950928
Swissprot:Q96E93,O88713
Background Information:Killer cell lectin-like receptor G1 (KLRG1) is the mouse homolog of the rat mast cell function-associated antigen (MAFA or 2F1-Ag). KLRG1 is a type II membrane glycoprotein that was first identified on the surface of rat mast cell line RBL-2H3. It is composed of a homodimer of glycosylated 30-38 kD subunits. Mouse and human homologs of KLRG1 are expressed by subsets of NK cells and lymphokine-activated killer (LAK) cells but not mast cells. KLRG1 is also expressed on subsets of CD8+ and CD4+ cells, including CD4+ and CD8+ effector/memory cells, potent regulatory CD4+ T cells. KLRG1 may be involved in regulating NK cell homeostasis. KLRG2 was found to recognize cadherins and thus inhibit immune responses by regulating the effector function and the developmental processes of NK and T cells.
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