Purified Anti-Human CD22 Antibody [HIB22]
- SKU:
- AGEL3516
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Applications:
- FCM
- Reactivity:
- Human
- Host Species:
- Mouse
- Isotype:
- Mouse IgG1, k
- Clone:
- HIB22
- Conjugation:
- Unconjugated
Description
Product Name: | Purified Anti-Human CD22 Antibody [HIB22] |
Product Code: | AGEL3516 |
Size: | 25ug, 100ug |
Clone No: | HIB22 |
Synonyms: | B-cell receptor CD22, Cd22, B-lymphocyte cell adhesion molecule, BL-CAM, Sialic acid-binding Ig-like lectin 2, Siglec-2, T-cell surface antigen Leu-14, CD22, Lyb-8, Siglec2 |
Reactivity: | Human |
Host Species: | Mouse |
Applications: | FCM |
Isotype: | Mouse IgG1, κ |
Isotype Control: | Purified Mouse IgG1, κ Isotype Control [MOPC-21] |
Conjugation: | Unconjugated |
Applications: | FCM |
Recommended Dilution: | Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 2.0 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. |
Storage Buffer: | Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer. |
Storage: | Keep as concentrated solution. Store at 2-8°C. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase. |
Shipping: | Biological ice pack at 4°C |
Form: | Liquid |
Gene ID: | 933 |
Swissprot: | P20273 |
Background Information: | CD22 is a 130 kD type I transmembrane glycoprotein also known as Siglec-2 and BL-CAM. It is a member of the immunoglobulin superfamily (sialoadhesion subgroup). CD22 is expressed in the cytoplasm of pro-B and pre-B cells, and on the surface of mature B and activated B cells, but not on plasma cells. CD22 is present in the B cell receptor complex and associates with SHP-1, Syk, Lck, Lyn, and phospholipase Cγ1. A primary function of CD22 is thought to be in limiting antigen receptor signaling by modulating B cell activation threshold. CD22 has been shown to bind to CD45RO and CD75, although the natural ligands for this molecule remain controversial. |