ptxA Antibody (PACO34674)
- SKU:
- PACO34674
- Product Type:
- Antibody
- Reactivity:
- Bacteria
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | ptxA Antibody (PACO34674) |
| Antibody SKU: | PACO34674 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000 |
| Species Reactivity: | Bordetella pertussis |
| Immunogen: | Recombinant Bordetella pertussis Pertussis toxin subunit 1 protein (35-269AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot. All lanes: Bordella pertussis pertussis toxin subunit 1 antibody at 2µg/ml + recombinant Bordella pertussis pertussis toxin subunit 1 100ng. Secondary. Goat polyclonal to rabbit IgG at 1/1000 dilution. Predicted band size: 36 kDa. Observed band size: 36 kDa. |
| Background: | S1 is an NAD-dependent ADP-ribosyltransferase, which plays a crucial role in the pathogenesis of B.pertussis causing disruption of normal host cellular regulation. It catalyzes the ADP-ribosylation of a cysteine in the α subunit of host heterotrimeric G proteins. In the absence of G proteins it also catalyzes the cleavage of NAD+ into ADP-ribose and nicotinamide. It irreversibly uncouples the G-α GTP-binding proteins from their membrane receptors. |
| Synonyms: | Pertussis toxin subunit 1 (PTX S1) (Islet-activating protein S1) (IAP S1) (NAD-dependent ADP-ribosyltransferase) (EC 2.4.2.-), ptxA |
| UniProt Protein Function: | S1 is an NAD-dependent ADP-ribosyltransferase, which plays a crucial role in the pathogenesis of B.pertussis causing disruption of normal host cellular regulation. It catalyzes the ADP-ribosylation of a cysteine in the alpha subunit of host heterotrimeric G proteins. In the absence of G proteins it also catalyzes the cleavage of NAD+ into ADP-ribose and nicotinamide. It irreversibly uncouples the G-alpha GTP-binding proteins from their membrane receptors. |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | P04977 |
| NCBI GenInfo Identifier: | 33594638 |
| NCBI Gene ID: | 2665068 |
| NCBI Accession: | NP_882282.1 |
| UniProt Secondary Accession: | P04977,O69258, O70057, Q599G4, Q5EIB9, Q93V22 |
| UniProt Related Accession: | P04977 |
| Molecular Weight: | |
| NCBI Full Name: | pertussis toxin subunit 1 |
| NCBI Synonym Full Names: | |
| NCBI Official Symbol: | ptxA |
| NCBI Official Synonym Symbols: | |
| NCBI Protein Information: | pertussis toxin subunit 1 |
| UniProt Protein Name: | Pertussis toxin subunit 1 |
| UniProt Synonym Protein Names: | Islet-activating protein S1; IAP S1; NAD-dependent ADP-ribosyltransferase (EC:2.4.2.-) |
| Protein Family: | Pertussis toxin |
| UniProt Gene Name: | ptxA |
| UniProt Entry Name: | TOX1_BORPE |
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