Name: PTGIS Antibody (PACO22775)
SKU: PACO22775
Availability: OutOfStock

Antibody Name:	PTGIS Antibody (PACO22775)
Antibody SKU:	PACO22775
Size:	100ul
Host Species:	Rabbit
Tested Applications:	ELISA, WB
Recommended Dilutions:	ELISA:1:2000-1:10000, WB:1:500-1:3000
Species Reactivity:	Human, Mouse, Rat
Immunogen:	Synthesized peptide derived from Internal of human PTGIS.

Form:	Liquid
Storage Buffer:	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

Western blot analysis of extracts from K562 cells, using PTGIS antibody.

Background:	Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2).
Synonyms:	CYP8; CYP8A1; cytochrome P450; family 8; subfamily A

UniProt Protein Function:	PTGIS: Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2). Belongs to the cytochrome P450 family.
UniProt Protein Details:	Protein type:Lipid Metabolism - arachidonic acid; Membrane protein, integral; Isomerase; EC 5.3.99.4; Endoplasmic reticulum Chromosomal Location of Human Ortholog: 20q13.13 Cellular Component: extracellular space; endoplasmic reticulum membrane; endoplasmic reticulum; integral to membrane; caveola; nucleus Molecular Function:protein binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; iron ion binding; heme binding; prostaglandin-I synthase activity; monooxygenase activity Biological Process: positive regulation of angiogenesis; vitamin metabolic process; NAD metabolic process; inhibition of NF-kappaB transcription factor; nicotinamide metabolic process; negative regulation of nitric oxide biosynthetic process; negative regulation of inflammatory response; xenobiotic metabolic process; cyclooxygenase pathway; icosanoid metabolic process; arachidonic acid metabolic process; prostaglandin biosynthetic process; water-soluble vitamin metabolic process Disease: Hypertension, Essential
NCBI Summary:	This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to prostacyclin (prostaglandin I2), a potent vasodilator and inhibitor of platelet aggregation. An imbalance of prostacyclin and its physiological antagonist thromboxane A2 contribute to the development of myocardial infarction, stroke, and atherosclerosis. [provided by RefSeq, Jul 2008]
UniProt Code:	Q16647
NCBI GenInfo Identifier:	2493373
NCBI Gene ID:	5740
NCBI Accession:	Q16647.1
UniProt Secondary Accession:	Q16647,Q3MII8, Q9HAX2, Q9HAX3, Q9HAX4,
UniProt Related Accession:	Q16647
Molecular Weight:	57,104 Da
NCBI Full Name:	Prostacyclin synthase
NCBI Synonym Full Names:	prostaglandin I2 (prostacyclin) synthase
NCBI Official Symbol:	PTGIS
NCBI Official Synonym Symbols:	CYP8; PGIS; PTGI; CYP8A1
NCBI Protein Information:	prostacyclin synthase; cytochrome P450, family 8, subfamily A, polypeptide 1; prostaglandin I2 synthase
UniProt Protein Name:	Prostacyclin synthase
UniProt Synonym Protein Names:	Prostaglandin I2 synthase
Protein Family:	Prostacyclin receptor
UniProt Gene Name:	PTGIS
UniProt Entry Name:	PTGIS_HUMAN

Antibodies	ELISA Kits
PTGIS Antibody (PACO04809)	Human PTGIS / Prostaglandin I Synthase ELISA Kit
	Human PTGIS (Prostaglandin I Synthase) CLIA Kit (HUES01018)

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)