PTGIS Antibody (PACO04809)
- SKU:
- PACO04809
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | PTGIS Antibody |
| Antibody SKU: | PACO04809 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | WB:1:500-1:2000 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | synthesized peptide derived from the C-terminal region of human PGI2 synthase. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | PTGIS; CYP8; CYP8A1; Prostacyclin synthase; Prostaglandin I2 synthase |
| UniProt Protein Function: | PTGIS: Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2). Belongs to the cytochrome P450 family. |
| UniProt Protein Details: | Protein type:Lipid Metabolism - arachidonic acid; Membrane protein, integral; Isomerase; EC 5.3.99.4; Endoplasmic reticulum Chromosomal Location of Human Ortholog: 20q13.13 Cellular Component: extracellular space; endoplasmic reticulum membrane; endoplasmic reticulum; integral to membrane; caveola; nucleus Molecular Function:protein binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; iron ion binding; heme binding; prostaglandin-I synthase activity; monooxygenase activity Biological Process: positive regulation of angiogenesis; vitamin metabolic process; NAD metabolic process; inhibition of NF-kappaB transcription factor; nicotinamide metabolic process; negative regulation of nitric oxide biosynthetic process; negative regulation of inflammatory response; xenobiotic metabolic process; cyclooxygenase pathway; icosanoid metabolic process; arachidonic acid metabolic process; prostaglandin biosynthetic process; water-soluble vitamin metabolic process Disease: Hypertension, Essential |
| NCBI Summary: | This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to prostacyclin (prostaglandin I2), a potent vasodilator and inhibitor of platelet aggregation. An imbalance of prostacyclin and its physiological antagonist thromboxane A2 contribute to the development of myocardial infarction, stroke, and atherosclerosis. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q16647 |
| NCBI GenInfo Identifier: | 2493373 |
| NCBI Gene ID: | 5740 |
| NCBI Accession: | Q16647.1 |
| UniProt Secondary Accession: | Q16647,Q3MII8, Q9HAX2, Q9HAX3, Q9HAX4, |
| UniProt Related Accession: | Q16647 |
| Molecular Weight: | 57,104 Da |
| NCBI Full Name: | Prostacyclin synthase |
| NCBI Synonym Full Names: | prostaglandin I2 (prostacyclin) synthase |
| NCBI Official Symbol: | PTGIS |
| NCBI Official Synonym Symbols: | CYP8; PGIS; PTGI; CYP8A1 |
| NCBI Protein Information: | prostacyclin synthase; cytochrome P450, family 8, subfamily A, polypeptide 1; prostaglandin I2 synthase |
| UniProt Protein Name: | Prostacyclin synthase |
| UniProt Synonym Protein Names: | Prostaglandin I2 synthase |
| Protein Family: | Prostacyclin receptor |
| UniProt Gene Name: | PTGIS |
| UniProt Entry Name: | PTGIS_HUMAN |
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