PTGDR2 Antibody (PACO02091)
- SKU:
- PACO02091
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | PTGDR2 Antibody |
| Antibody SKU: | PACO02091 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | WB:1:500-1:2000 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | synthesized peptide derived from the Internal region of human CD294. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | PTGDR2; CRTH2; DL1R; GPR44; Prostaglandin D2 receptor 2; Chemoattractant receptor-homologous molecule expressed on Th2 cells; G-protein coupled receptor 44; CD294 |
| UniProt Protein Function: | Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin-sensitive decreases in cAMP levels and Ca2+ mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses. |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a G-protein-coupled receptor that is preferentially expressed in CD4+ effector T helper 2 (Th2) cells. This protein is a prostaglandin D2 receptor that mediates the pro-inflammatory chemotaxis of eosinophils, basophils, and Th2 lymphocytes generated during allergic inflammation. Single nucleotide polymorphisms in the 3' UTR of this gene have been associated with asthma susceptibility.[provided by RefSeq, Mar 2011] |
| UniProt Code: | Q9Y5Y4 |
| NCBI GenInfo Identifier: | 153791424 |
| NCBI Gene ID: | 11251 |
| NCBI Accession: | NP_004769.2 |
| UniProt Secondary Accession: | Q9Y5Y4,O94765, Q4QRI6 |
| UniProt Related Accession: | Q9Y5Y4 |
| Molecular Weight: | 43,268 Da |
| NCBI Full Name: | prostaglandin D2 receptor 2 |
| NCBI Synonym Full Names: | prostaglandin D2 receptor 2 |
| NCBI Official Symbol: | PTGDR2 |
| NCBI Official Synonym Symbols: | DP2; DL1R; CD294; CRTH2; GPR44 |
| NCBI Protein Information: | prostaglandin D2 receptor 2 |
| UniProt Protein Name: | Prostaglandin D2 receptor 2 |
| UniProt Synonym Protein Names: | Chemoattractant receptor-homologous molecule expressed on Th2 cells; G-protein coupled receptor 44; CD_antigen: CD294 |
| Protein Family: | |
| UniProt Gene Name: | PTGDR2 |
| UniProt Entry Name: |
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