PTAFR Antibody (PACO04803)
- SKU:
- PACO04803
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | PTAFR Antibody |
| Antibody SKU: | PACO04803 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IF |
| Recommended Dilutions: | IF:1:200-1:1000 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | synthesized peptide derived from the Internal region of human PAF-R. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | PTAFR; PAFR; Platelet-activating factor receptor; PAF-R; PAFr |
| UniProt Protein Function: | PTAFR: Receptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth- muscle contractile and hypotensive activity. Seems to mediate its action via a G protein that activates a phosphatidylinositol- calcium second messenger system. Belongs to the G-protein coupled receptor 1 family.Protein type: Membrane protein, integral; GPCR, family 1; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCRChromosomal Location of Human Ortholog: 1p35-p34.3Cellular Component: nucleoplasm; membrane; intracellular membrane-bound organelle; integral to plasma membrane; integral to membrane; plasma membraneMolecular Function: G-protein coupled receptor activity; platelet activating factor receptor activity; purinergic nucleotide receptor activity, G-protein coupled; lipopolysaccharide binding; phospholipid binding; lipopolysaccharide receptor activityBiological Process: G-protein coupled receptor protein signaling pathway; phosphoinositide-mediated signaling; inositol trisphosphate biosynthetic process; cytokine and chemokine mediated signaling pathway; lipopolysaccharide-mediated signaling pathway; cytokine production; immune response; inflammatory response; chemotaxis |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a seven-transmembrane G-protein-coupled receptor for platelet-activating factor (PAF) that localizes to lipid rafts and/or caveolae in the cell membrane. PAF (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) is a phospholipid that plays a significant role in oncogenic transformation, tumor growth, angiogenesis, metastasis, and pro-inflammatory processes. Binding of PAF to the PAF-receptor (PAFR) stimulates numerous signal transduction pathways including phospholipase C, D, A2, mitogen-activated protein kinases (MAPKs), and the phosphatidylinositol-calcium second messenger system. Following PAFR activation, cells become rapidly desensitized and this refractory state is dependent on PAFR phosphorylation, internalization, and down-regulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011] |
| UniProt Code: | P25105 |
| NCBI GenInfo Identifier: | 257900493 |
| NCBI Gene ID: | 5724 |
| NCBI Accession: | NP_001158195.1 |
| UniProt Secondary Accession: | P25105,A3KMC8, A8K2H5 |
| UniProt Related Accession: | P25105 |
| Molecular Weight: | 39,203 Da |
| NCBI Full Name: | platelet-activating factor receptor |
| NCBI Synonym Full Names: | platelet-activating factor receptor |
| NCBI Official Symbol: | PTAFR |
| NCBI Official Synonym Symbols: | PAFR |
| NCBI Protein Information: | platelet-activating factor receptor; PAF-R |
| UniProt Protein Name: | Platelet-activating factor receptor |
| UniProt Synonym Protein Names: | |
| Protein Family: | |
| UniProt Gene Name: | PTAFR |
| UniProt Entry Name: | PTAFR_HUMAN |
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