PSMB11 Antibody (PACO11531)
- SKU:
- PACO11531
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | PSMB11 Antibody (PACO11531) |
| Antibody SKU: | PACO11531 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | |
| Species Reactivity: | Human |
| Immunogen: | Human PSMB11 |
| Form: | Liquid |
| Storage Buffer: | PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
| Purification Method: | Antigen Affinity purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | proteasome (prosome, macropain) subunit, β type, 11;PSMB11;FLJ16369;beta5t ; |
| UniProt Protein Function: | PSMB11: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Incorporated instead of PSMB5 or PSMB8, this unit reduces the chymotrypsin-like activity of the proteasome. Plays a pivotal role in development of CD8-positive T cells. Belongs to the peptidase T1B family.Protein type: EC 3.4.25.1; Protease; Proteasome complexChromosomal Location of Human Ortholog: 14q11.2Cellular Component: cytosolMolecular Function: peptidase activityBiological Process: anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; MAPKKK cascade; positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; proteasomal ubiquitin-dependent protein catabolic process; protein polyubiquitination; proteolysis; regulation of amino acid metabolic process; regulation of mRNA stability; stimulatory C-type lectin receptor signaling pathway; T cell receptor signaling pathway; tumor necrosis factor-mediated signaling pathway; Wnt receptor signaling pathway, planar cell polarity pathway |
| UniProt Protein Details: | |
| NCBI Summary: | Proteasomes generate peptides that are presented by major histocompatibility complex (MHC) I molecules to other cells of the immune system. Proteolysis is conducted by 20S proteasomes, complexes of 28 subunits arranged as a cylinder in 4 heteroheptameric rings: alpha-1 to -7, beta-1 to -7, beta-1 to -7, and alpha-1 to -7. The catalytic subunits are beta-1 (PSMB6; MIM 600307), beta-2 (PSMB7; MIM 604030), and beta-5 (PSMB5; MIM 600306). Three additional subunits, beta-1i (PSMB9; MIM 177045), beta-2i (PSMB10; MIM 176847), and beta-5i (PSMB8; MIM 177046), are induced by gamma-interferon (IFNG; MIM 147570) and are preferentially incorporated into proteasomes to make immunoproteasomes. PSMB11, or beta-5t, is a catalytic subunit expressed exclusively in cortical thymic epithelial cells (Murata et al., 2007 [PubMed 17540904]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | A5LHX3 |
| NCBI GenInfo Identifier: | 158513330 |
| NCBI Gene ID: | 122706 |
| NCBI Accession: | A5LHX3.1 |
| UniProt Secondary Accession: | A5LHX3 |
| UniProt Related Accession: | A5LHX3 |
| Molecular Weight: | 32,530 Da |
| NCBI Full Name: | Proteasome subunit beta type-11 |
| NCBI Synonym Full Names: | proteasome subunit beta 11 |
| NCBI Official Symbol: | PSMB11 |
| NCBI Official Synonym Symbols: | BETA5T |
| NCBI Protein Information: | proteasome subunit beta type-11 |
| UniProt Protein Name: | Proteasome subunit beta type-11 |
| UniProt Synonym Protein Names: | Proteasome subunit beta-5t |
| Protein Family: | Proteasome |
| UniProt Gene Name: | PSMB11 |
| UniProt Entry Name: | PSB11_HUMAN |
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