Name: PSD Antibody (PACO54042)
SKU: PACO54042
Availability: OutOfStock

Antibody Name:	PSD Antibody (PACO54042)
Antibody SKU:	PACO54042
Size:	50ug
Host Species:	Rabbit
Tested Applications:	ELISA, WB, IHC
Recommended Dilutions:	ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:20-1:200
Species Reactivity:	Human
Immunogen:	Recombinant Human PH and SEC7 domain-containing protein 1 protein (247-489AA)

Form:	Liquid
Storage Buffer:	Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method:	>95%, Protein G purified
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

	Western Blot. Positive WB detected in: MCF-7 whole cell lysate. All lanes: PSD antibody at 3.2µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 110, 71 kDa. Observed band size: 110 kDa.
	Immunohistochemistry of paraffin-embedded human small intestine tissue using PACO54042 at dilution of 1:100.
	Immunohistochemistry of paraffin-embedded human brain tissue using PACO54042 at dilution of 1:100.

Background:	Guanine nucleotide exchange factor for ARF6. Induces cytoskeletal remodeling (By similarity).
Synonyms:	PH and SEC7 domain-containing protein 1 (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6) (Exchange factor for ARF6) (Exchange factor for ARF6 A) (Pleckstrin homology and SEC7 domain-containing protein 1), PSD, EFA6 EFA6A KIAA2011 PSD1 TYL

UniProt Protein Function:	PSD: Guanine nucleotide exchange factor for ARF6. Induces cytoskeletal remodeling. Belongs to the PSD family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: GEFs; GEFs, ARFChromosomal Location of Human Ortholog: 10q24Cellular Component: ruffle; integral to membrane; plasma membrane; trans-Golgi network; cell junctionMolecular Function: signal transducer activity; protein binding; phospholipid binding; ARF guanyl-nucleotide exchange factor activityBiological Process: vesicle-mediated transport; neuron differentiation; regulation of ARF protein signal transduction; signal transduction; positive regulation of GTPase activity
UniProt Protein Details:
NCBI Summary:	This gene encodes a Plekstrin homology and SEC7 domains-containing protein that functions as a guanine nucleotide exchange factor. The encoded protein regulates signal transduction by activating ADP-ribosylation factor 6. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
UniProt Code:	A5PKW4
NCBI GenInfo Identifier:	402534559
NCBI Gene ID:	5662
NCBI Accession:	NP_001257894.1
UniProt Secondary Accession:	A5PKW4,Q15673, Q8IVG0, B1AKX7, D3DR87
UniProt Related Accession:	A5PKW4
Molecular Weight:	70,393 Da
NCBI Full Name:	PH and SEC7 domain-containing protein 1 isoform 1
NCBI Synonym Full Names:	pleckstrin and Sec7 domain containing
NCBI Official Symbol:	PSD
NCBI Official Synonym Symbols:	TYL; EFA6; PSD1; EFA6A
NCBI Protein Information:	PH and SEC7 domain-containing protein 1
UniProt Protein Name:	PH and SEC7 domain-containing protein 1
UniProt Synonym Protein Names:	Exchange factor for ARF6; Pleckstrin homology and SEC7 domain-containing protein 1
Protein Family:	PH and SEC7 domain-containing protein
UniProt Gene Name:	PSD
UniProt Entry Name:	PSD1_HUMAN