PRUNE2 Antibody (PACO44244)
- SKU:
- PACO44244
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | PRUNE2 Antibody (PACO44244) |
| Antibody SKU: | PACO44244 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Protein prune homolog 2 protein (1-250AA) |
| Form: | Liquid |
| Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Purification Method: | Antigen Affinity Purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human kidney tissue using PACO44244 at dilution of 1:100. |
 | Immunohistochemistry of paraffin-embedded human brain tissue using PACO44244 at dilution of 1:100. |
| Background: | May play an important role in regulating differentiation, survival and aggressiveness of the tumor cells. |
| Synonyms: | Protein prune homolog 2 (BNIP2 motif-containing molecule at the C-terminal region 1), PRUNE2, BMCC1 BNIPXL C9orf65 KIAA0367 |
| UniProt Protein Function: | |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene belongs to the B-cell CLL/lymphoma 2 and adenovirus E1B 19 kDa interacting family, whose members play roles in many cellular processes including apotosis, cell transformation, and synaptic function. Several functions for this protein have been demonstrated including suppression of Ras homolog family member A activity, which results in reduced stress fiber formation and suppression of oncogenic cellular transformation. A high molecular weight isoform of this protein has also been shown to colocalize with Adaptor protein complex 2, beta-Adaptin and endodermal markers, suggesting an involvement in post-endocytic trafficking. In prostate cancer cells, this gene acts as a tumor suppressor and its expression is regulated by prostate cancer antigen 3, a non-protein coding gene on the opposite DNA strand in an intron of this gene. Prostate cancer antigen 3 regulates levels of this gene through formation of a double-stranded RNA that undergoes adenosine deaminase actin on RNA-dependent adenosine-to-inosine RNA editing. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015] |
| UniProt Code: | Q8WUY3 |
| NCBI GenInfo Identifier: | 162287219 |
| NCBI Gene ID: | 158471 |
| NCBI Accession: | NP_056040.2 |
| UniProt Secondary Accession: | Q8WUY3 |
| UniProt Related Accession: | Q8WUY3 |
| Molecular Weight: | 150 kDa |
| NCBI Full Name: | protein prune homolog 2 isoform 1 |
| NCBI Synonym Full Names: | prune homolog 2 with BCH domain |
| NCBI Official Symbol: | PRUNE2 |
| NCBI Official Synonym Symbols: | BMCC1; BNIPXL; C9orf65; KIAA0367 |
| NCBI Protein Information: | protein prune homolog 2 |
| UniProt Protein Name: | Protein prune homolog 2 |
| UniProt Synonym Protein Names: | BNIP2 motif-containing molecule at the C-terminal region 1 |
| Protein Family: | Protein prune |
| UniProt Gene Name: | PRUNE2 |
| UniProt Entry Name: | PRUN2_HUMAN |
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