| UniProt Protein Function: | PRUNE: Phosphodiesterase (PDE) that has higher activity toward cAMP than cGMP, as substrate. Plays a role in cell proliferation, is able to induce cell motility and acts as a negative regulator of NME1. Belongs to the PPase class C family. Prune subfamily. 7 isoforms of the human protein are produced by alternative splicing.Protein type: Hydrolase; EC 3.6.1.1; Nucleotide Metabolism - purineChromosomal Location of Human Ortholog: 1q21Cellular Component: cytoplasmMolecular Function: protein binding |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a member of the DHH protein superfamily of phosphoesterases. This protein has been found to function as both a nucleotide phosphodiesterase and an exopolyphosphatase. This protein is believed to stimulate cancer progression and metastases through the induction of cell motility. A pseuodgene has been identified on chromosome 13. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014] |
| UniProt Code: | Q86TP1 |
| NCBI GenInfo Identifier: | 229462737 |
| NCBI Gene ID: | 58497 |
| NCBI Accession: | Q86TP1.2 |
| UniProt Secondary Accession: | Q86TP1,Q5SZF9, Q659E5, Q6P4E0, Q8N654, Q96JU5, Q9C071 Q9C072, Q9UIV0, B2RCH8 |
| UniProt Related Accession: | Q86TP1 |
| Molecular Weight: | 24,475 Da |
| NCBI Full Name: | Protein prune homolog |
| NCBI Synonym Full Names: | prune exopolyphosphatase |
| NCBI Official Symbol: | PRUNE1 |
| NCBI Official Synonym Symbols: | PRUNE; DRES17; HTCD37; DRES-17; H-PRUNE |
| NCBI Protein Information: | protein prune homolog |
| UniProt Protein Name: | Protein prune homolog |
| UniProt Synonym Protein Names: | Drosophila-related expressed sequence 17; DRES-17; DRES17; HTcD37 |
| Protein Family: | Protein prune |
| UniProt Gene Name: | PRUNE |
| UniProt Entry Name: | PRUNE_HUMAN |
