Prnp Antibody (PACO29180)
- SKU:
- PACO29180
- Product Type:
- Antibody
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | Prnp Antibody (PACO29180) |
| Antibody SKU: | PACO29180 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA |
| Recommended Dilutions: | |
| Species Reactivity: | Rat |
| Immunogen: | Recombinant Rat Major prion protein (29-231AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Background: | Its primary physiological function is unclear. Has cytoprotective activity against internal or environmental stresses. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains. |
| Synonyms: | Major prion protein (PrP) (CD antigen CD230), Prnp, Prn Prp |
| UniProt Protein Function: | |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that tends to aggregate into rod-like structures. The encoded protein contains a highly unstable region of five tandem octapeptide repeats. This gene is found on chromosome 20, approximately 20 kbp upstream of a gene which encodes a biochemically and structurally similar protein to the one encoded by this gene. Mutations in the repeat region as well as elsewhere in this gene have been associated with Creutzfeldt-Jakob disease, fatal familial insomnia, Gerstmann-Straussler disease, Huntington disease-like 1, and kuru. An overlapping open reading frame has been found for this gene that encodes a smaller, structurally unrelated protein, AltPrp. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014] |
| UniProt Code: | P13852 |
| NCBI GenInfo Identifier: | 4506113 |
| NCBI Gene ID: | 5621 |
| NCBI Accession: | NP_000302.1 |
| UniProt Secondary Accession: | P13852,P04925, P13852 |
| UniProt Related Accession: | P13852,P04156, F7VJQ1 |
| Molecular Weight: | 28kDa |
| NCBI Full Name: | major prion protein preproprotein Prp |
| NCBI Synonym Full Names: | prion protein |
| NCBI Official Symbol: | PRNP |
| NCBI Official Synonym Symbols: | CJD; GSS; PrP; ASCR; KURU; PRIP; PrPc; CD230; AltPrP; p27-30; PrP27-30; PrP33-35C |
| NCBI Protein Information: | major prion protein; alternative prion protein |
| UniProt Protein Name: | Major prion protein |
| UniProt Synonym Protein Names: | ASCR; PrP27-30; PrP33-35C |
| Protein Family: | Prion-like protein doppel |
| UniProt Gene Name: | PRNP |
| UniProt Entry Name: | PRIO_HUMAN |
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