PRKC α/β Polyclonal Antibody
- SKU:
- CAB23439
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
| Product Name: | PRKC α/β Polyclonal Antibody |
| Product Code: | CAB23439 |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Western blotting |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB, ELISA |
| Key Applications: | Western blotting |
| Recommended Dilution: | WB 1:500-1:1000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3. |
| Positive Samples: | NIH/3T3, Jurkat, C6, SH-SY5Y, Mouse brain, Rat brain |
| Cellular Location: | Cell membrane, Cytoplasm, Mitochondrion membrane, Nucleus, Peripheral membrane protein |
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes.
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 573-672 of human PKC alpha (NP_002728.2). |
| Sequence: | MTKHP AKRLG CGPEG ERDVR EHAFF RRIDW EKLEN REIQP PFKPK VCGKG AENFD KFFTR GQPVL TPPDQ LVIAN IDQSD FEGFS YVNPQ FVHPI LQSAV |
| Synonyms: | AAG6, PKCA, PRKACA, PKCI+/-, PKCalpha, PKC-alpha |
| Calculated MW: | 77kDa |
| Observed MW: | 80kDa |
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