Prion Protein Polyclonal Antibody
- SKU:
- CAB21570
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
| Product Name: | Prion Protein Polyclonal Antibody |
| Product Code: | CAB21570 |
| Reactivity: | Human |
| Applications: | Western blotting |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Reactivity: | Human |
| Tested Applications: | WB, ELISA |
| Key Applications: | Western blotting |
| Recommended Dilution: | WB 1:500-1:2000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Cellular Location: | Cell membrane, Cytoplasm, GPI-anchor, Golgi apparatus, Lipid-anchor, Nucleus |
The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that tends to aggregate into rod-like structures. The encoded protein contains a highly unstable region of five tandem octapeptide repeats. This gene is found on chromosome 20, approximately 20 kbp upstream of a gene which encodes a biochemically and structurally similar protein to the one encoded by this gene. Mutations in the repeat region as well as elsewhere in this gene have been associated with Creutzfeldt-Jakob disease, fatal familial insomnia, Gerstmann-Straussler disease, Huntington disease-like 1, and kuru. An overlapping open reading frame has been found for this gene that encodes a smaller, structurally unrelated protein, AltPrp. Alternative splicing results in multiple transcript variants.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 23-230 of human Prion Protein (NP_001073592.1). |
| Sequence: | KKRPK PGGWN TGGSR YPGQG SPGGN RYPPQ GGGGW GQPHG GGWGQ PHGGG WGQPH GGGWG QPHGG GWGQG GGTHS QWNKP SKPKT NMKHM AGAAA AGAVV GGLGG YMLGS AMSRP IIHFG SDYED RYYRE NMHRY PNQVY YRPMD EYSNQ NNFVH DCVNI TIKQH TVTTT TKGEN FTETD VKMME RVVEQ MCITQ YERES QAYYQ RGS |
| Synonyms: | CJD, GSS, PrP, ASCR, KURU, PRIP, PrPc, CD230, AltPrP, p27-30, PrP27-30, PrP33-35C |
| Calculated MW: | 28kDa |
| Observed MW: | Refer to figures |
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