PRG2 Polyclonal Antibody
- SKU:
- CAB24855
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- Applications:
- IF
Description
| Product Name: | PRG2 Polyclonal Antibody |
| Product Code: | CAB24855 |
| Reactivity: | Human |
| Applications: | Western blotting, Immunofluorescence |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Reactivity: | Human |
| Tested Applications: | WB, IF/ICC |
| Key Applications: | Western blotting, Immunofluorescence |
| Recommended Dilution: | IF/ICC 1:50-1:200 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3. |
| Cellular Location: | Cytoplasmic vesicle, Secreted, secretory vesicle |
The protein encoded by this gene is the predominant constituent of the crystalline core of the eosinophil granule. High levels of the proform of this protein are also present in placenta and pregnancy serum, where it exists as a complex with several other proteins including pregnancy-associated plasma protein A (PAPPA), angiotensinogen (AGT), and C3dg. This protein may be involved in antiparasitic defense mechanisms as a cytotoxin and helminthotoxin, and in immune hypersensitivity reactions. The encoded protein contains a peptide that displays potent antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria, and fungi. It is directly implicated in epithelial cell damage, exfoliation, and bronchospasm in allergic diseases. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 17-222 of human PRG2(NP_002719.3). |
| Sequence: | LHLRS ETSTF ETPLG AKTLP EDEET PEQEM EETPC RELEE EEEWG SGSED ASKKD GAVES ISVPD MVDKN LTCPE EEDTV KVVGI PGCQT CRYLL VRSLQ TFSQA WFTCR RCYRG NLVSI HNFNI NYRIQ CSVSA LNQGQ VWIGG RITGS GRCRR FQWVD GSRWN FAYWA AHQPW SRGGH CVALC TRGGH WRRAH CLRRL PFICS Y |
| Synonyms: | PRG2, BMPG, MBP, MBP1, proMBP, bone marrow proteoglycan |
| Calculated MW: | 23kDa/25kDa |
| Observed MW: | Refer to figures |
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