PRA1 Antibody (PACO61782)
- SKU:
- PACO61782
- Product Type:
- Antibody
- Reactivity:
- Fungus
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | PRA1 Antibody (PACO61782) |
| Antibody SKU: | PACO61782 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000 |
| Species Reactivity: | Candida albicans |
| Immunogen: | Recombinant Candida albicans pH-regulated antigen PRA1 protein (16-299AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot. Positive WB detected in Recombinant protein. All lanes: PRA1 antibody at 4.7µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 55 kDa. Observed band size: 55 kDa. |
| Background: | Cell surface protein involved in the host-parasite interaction during candidal infection. With MP65, represents a major component of the biofilm matrix. Sequesters zinc from host tissue and mediates leukocyte adhesion and migration. As a surface protein, binds the two human complement regulators CFH and CFHR1, as well as plasminogen PLG, mediates complement evasion and extra-cellular matrix interaction and/or degradation. As a released protein, enhances complement control in direct vicinity of the yeast and thus generates an additional protective layer which controls host complement attack, assisting the fungus in escaping host surveillance. Binds to host fluid-phase C3 and blocks cleavage of C3 to C3a and C3b, leading to inhibition of complement activation. Mediates also human complement control and complement evasion through binding to C4BPA, another human complement inhibitor, as well as through binding to host integrin alpha-M/beta-2. Decreases complement-mediated adhesion, as well as uptake of C.albicans by human macrophages. |
| Synonyms: | pH-regulated antigen PRA1 (58 kDa fibrinogen-binding mannoprotein), PRA1, FBP1 |
| UniProt Protein Function: | Cell surface protein involved in the host-parasite interaction during candidal infection. With MP65, represents a major component of the biofilm matrix. Sequesters zinc from host tissue and mediates leukocyte adhesion and migration. As a surface protein, binds the two human complement regulators CFH and CFHR1, as well as plasminogen PLG, mediates complement evasion and extra-cellular matrix interaction and/or degradation. As a released protein, enhances complement control in direct vicinity of the yeast and thus generates an additional protective layer which controls host complement attack, assisting the fungus in escaping host surveillance. Binds to host fluid-phase C3 and blocks cleavage of C3 to C3a and C3b, leading to inhibition of complement activation. Mediates also human complement control and complement evasion through binding to C4BPA, another human complement inhibitor, as well as through binding to host integrin alpha-M/beta-2. Decreases complement-mediated adhesion, as well as uptake of C.albicans by human macrophages. |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | P87020 |
| NCBI GenInfo Identifier: | 1111956962 |
| NCBI Gene ID: | 3642969 |
| NCBI Accession: | XP_715420.2 |
| UniProt Secondary Accession: | P87020,P78598, Q5A0Y5, Q5A156, A0A1D8PMQ8 |
| UniProt Related Accession: | P87020 |
| Molecular Weight: | 33.4 kDa |
| NCBI Full Name: | Pra1p |
| NCBI Synonym Full Names: | |
| NCBI Official Symbol: | PRA1 |
| NCBI Official Synonym Symbols: | |
| NCBI Protein Information: | Pra1p |
| UniProt Protein Name: | pH-regulated antigen PRA1 |
| UniProt Synonym Protein Names: | 58 kDa fibrinogen-binding mannoprotein |
| Protein Family: | Pheromone receptor |
| UniProt Gene Name: | PRA1 |
| UniProt Entry Name: |
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