PPP1R16B Antibody (PACO39054)
- SKU:
- PACO39054
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | PPP1R16B Antibody (PACO39054) |
| Antibody SKU: | PACO39054 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Protein phosphatase 1 regulatory inhibitor subunit 16B protein (101-400AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human lung tissue using PACO39054 at dilution of 1:100. |
 | Immunohistochemistry of paraffin-embedded human kidney tissue using PACO39054 at dilution of 1:100. |
| Background: | Regulator of protein phosphatase 1 (PP1) that acts as a positive regulator of pulmonary endothelial cell (EC) barrier function. Involved in PKA-mediated moesin dephosphorylation which is important in EC barrier protection against thrombin stimulation. Promotes the interaction of PPP1CA with RPSA/LAMR1 and in turn facilitates the dephosphorylation of RPSA/LAMR1. Involved in the regulation of endothelial cell filopodia extension. May be a downstream target for TGF-beta1 signaling cascade in endothelial cells. |
| Synonyms: | Protein phosphatase 1 regulatory inhibitor subunit 16B (Ankyrin repeat domain-containing protein 4) (CAAX box protein TIMAP) (TGF-beta-inhibited membrane-associated protein) (hTIMAP), PPP1R16B, ANKRD4 KIAA0823 |
| UniProt Protein Function: | PPP1R16B: Regulator of protein phosphatase 1 (PP1) that acts as a positive regulator of pulmonary endothelial cell (EC) barrier function. Involved in PKA-mediated moesin dephosphorylation which is important in EC barrier protection against thrombin stimulation. Promotes the interaction of PPP1CA with RPSA/LAMR1 and in turn facilitates the dephosphorylation of RPSA/LAMR1. Involved in the regulation of endothelial cell filopodia extension. May be a downstream target for TGF-beta1 signaling cascade in endothelial cells.Protein type: Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunitChromosomal Location of Human Ortholog: 20q11.23Cellular Component: cell projection; nucleus; perinuclear region of cytoplasm; plasma membraneMolecular Function: protein binding; protein phosphatase type 1 regulator activityBiological Process: negative regulation of protein amino acid dephosphorylation; positive regulation of endothelial cell proliferation; positive regulation of protein amino acid dephosphorylation; regulation of filopodium formation; regulation of phosphoinositide 3-kinase cascade |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene is membrane-associated and contains five ankyrin repeats, a protein phosphatase-1-interacting domain, and a carboxy-terminal CAAX box domain. Synthesis of the encoded protein is inhibited by transforming growth factor beta-1. The protein may bind to the membrane through its CAAX box domain and may act as a signaling molecule through interaction with protein phosphatase-1. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Sep 2015] |
| UniProt Code: | Q96T49 |
| NCBI GenInfo Identifier: | 22256977 |
| NCBI Gene ID: | 26051 |
| NCBI Accession: | Q96T49.1 |
| UniProt Secondary Accession: | Q96T49,O94912, Q5W9G4, Q9NQG4, A2RRR6, E9PFS8 |
| UniProt Related Accession: | Q96T49 |
| Molecular Weight: | 58,900 Da |
| NCBI Full Name: | Protein phosphatase 1 regulatory inhibitor subunit 16B |
| NCBI Synonym Full Names: | protein phosphatase 1 regulatory subunit 16B |
| NCBI Official Symbol: | PPP1R16B |
| NCBI Official Synonym Symbols: | TIMAP; ANKRD4 |
| NCBI Protein Information: | protein phosphatase 1 regulatory inhibitor subunit 16B |
| UniProt Protein Name: | Protein phosphatase 1 regulatory inhibitor subunit 16B |
| UniProt Synonym Protein Names: | Ankyrin repeat domain-containing protein 4; CAAX box protein TIMAP; TGF-beta-inhibited membrane-associated protein; hTIMAP |
| Protein Family: | Protein phosphatase 1 regulatory inhibitor |
| UniProt Gene Name: | PPP1R16B |
| UniProt Entry Name: | PP16B_HUMAN |
| Antibodies |
| PPP1R16B Antibody (PACO03811) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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