PPP1R14C Antibody (PACO00997)
- SKU:
- PACO00997
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IHC
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | PPP1R14C Antibody |
| Antibody SKU: | PACO00997 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC, IF |
| Recommended Dilutions: | WB:1:500-1:2000, IHC:1:100-1:300, IF:1:200-1:1000 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | synthesized peptide derived from the Internal region of human KEPI. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | PPP1R14C; KEPI; Protein phosphatase 1 regulatory subunit 14C; Kinase-enhanced PP1 inhibitor; PKC-potentiated PP1 inhibitory protein; Serologically defined breast cancer antigen NY-BR-81 |
| UniProt Protein Function: | KEPI: Inhibitor of PPP1CA. Has over 600-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction. Belongs to the PP1 inhibitor family. |
| UniProt Protein Details: | Protein type:Inhibitor; Protein phosphatase, regulatory subunit Chromosomal Location of Human Ortholog: 6q24.3-q25.3 Cellular Component: cytoplasm; membrane Molecular Function:type 1 serine/threonine specific protein phosphatase inhibitor activity Biological Process: negative regulation of catalytic activity; regulation of phosphorylation |
| NCBI Summary: | The degree of protein phosphorylation is regulated by a balance of protein kinase and phosphatase activities. Protein phosphatase-1 (PP1; see MIM 176875) is a signal-transducing phosphatase that influences neuronal activity, protein synthesis, metabolism, muscle contraction, and cell division. PPP1R14C is an inhibitor of PP1 (Liu et al., 2002 [PubMed 11812771]).[supplied by OMIM, Feb 2010] |
| UniProt Code: | Q8TAE6 |
| NCBI GenInfo Identifier: | 90110047 |
| NCBI Gene ID: | 81706 |
| NCBI Accession: | Q8TAE6.3 |
| UniProt Secondary Accession: | Q8TAE6,Q5VY83, Q96BB1, Q9H277, |
| UniProt Related Accession: | Q8TAE6 |
| Molecular Weight: | 17,843 Da |
| NCBI Full Name: | Protein phosphatase 1 regulatory subunit 14C |
| NCBI Synonym Full Names: | protein phosphatase 1 regulatory inhibitor subunit 14C |
| NCBI Official Symbol: | PPP1R14C |
| NCBI Official Synonym Symbols: | KEPI; NY-BR-81; CPI17-like |
| NCBI Protein Information: | protein phosphatase 1 regulatory subunit 14C |
| UniProt Protein Name: | Protein phosphatase 1 regulatory subunit 14C |
| UniProt Synonym Protein Names: | Kinase-enhanced PP1 inhibitor; PKC-potentiated PP1 inhibitory protein; Serologically defined breast cancer antigen NY-BR-81 |
| Protein Family: | Protein phosphatase 1 regulatory |
| UniProt Gene Name: | PPP1R14C |
| UniProt Entry Name: | PP14C_HUMAN |
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