PPP1R14A Monoclonal Antibody [P4H10AT] (CPAB0140)
![PPP1R14A Monoclonal Antibody [P4H10AT] (CPAB0140)](https://cdn11.bigcommerce.com/s-rd6ounxcu2/images/stencil/608x608/products/58366/63548/ppp1r14a-monoclonal-antibody-p4h10at-cpab0140__33586__96078.1706534986.jpg?c=1 "PPP1R14A Monoclonal Antibody [P4H10AT] (CPAB0140)")
- SKU:
- CPAB0140
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Host Species:
- Mouse
- Isotype:
- IgG2a
- Clone:
- P4H10AT
- Applications:
- WB
- Applications:
- ELISA
![PPP1R14A Monoclonal Antibody [P4H10AT] (CPAB0140)](https://cdn11.bigcommerce.com/s-rd6ounxcu2/images/stencil/1280x1280/products/58366/63548/ppp1r14a-monoclonal-antibody-p4h10at-cpab0140__33586__96078.1706534986.jpg?c=1&imbypass=on "PPP1R14A Monoclonal Antibody [P4H10AT] (CPAB0140)")
Description
system_update_alt Datasheet
| Product Name: | PPP1R14A Antibody |
| Product Sku: | CPAB0140 |
| Size: | 5μg |
| Host Species: | Mouse |
| Immunogen: | Anti-human PPP1R14A mAb is derived from hybridization of mouse FO myeloma cells with spleen cells from BALB/c mice immunized with recombinant human PPP1R14A amino acids 1-147 purified from Ecoli. |
| Clone: | P4H10AT. |
| Reactivity: | Human |
| Applications: | Western Blot, ELISA |
| Purification Method: | PPP1R14A antibody was purified from mouse ascitic fluids by protein-G affinity chromatography. |
| Isotype: | IgG2a |
| Background: | PPP1R14A is a phosphorylation-dependent inhibitor of smooth muscle myosin phosphatase. Inhibition of PPP1R14A results to increased myosin phosphorylation and enhances smooth muscle contraction in the absence of increased intracellular Ca(2+) concentration. Myosin phosphatase can reverse MYL (myosin light chain) phosphorylation to induce a state of relaxation. However, during agonist-induced contraction at constant Ca2+ concurrent inhibition of myosin phosphatase leads to increases in MYL phosphorylation and tension. These calcium-independent increases in myosin phosphorylation and tension are termed calcium sensitization. Human pregnancy is characterized by the increases of PKN1 expression and CPI-17 phosphorylation in the myometrium. PPP1R14A is mapped to chromosome 19q13.13-q13.2. PPP1R14A binds directly to protein kinase C and casein kinase I. PPP1R14A siRNA decreased the level of merlin phosphorylation and consequently Ras and ERK activity in human tumor cell lines. PKC/CPI-17 medi |
| Synonyms: | Protein phosphatase 1 regulatory subunit 14A, 17 kDa PKC-potentiated inhibitory protein of PP1, CPI17, CPI-17, PPP1INL, PPP1R14A. |
| Storage Buffer: | For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles. |
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