Ppp1cb Antibody (PACO51842)
- SKU:
- PACO51842
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | Ppp1cb Antibody (PACO51842) |
| Antibody SKU: | PACO51842 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000 |
| Species Reactivity: | Mouse, Rat |
| Immunogen: | Recombinant Mouse Serine/threonine-protein phosphatase PP1-β catalytic subunit protein (2-327AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot. Positive WB detected in: Rat liver tissue. All lanes: Ppp1cb antibody at 3µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 38 kDa. Observed band size: 38 kDa.. |
| Background: | Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. |
| Synonyms: | Serine/threonine-protein phosphatase PP1-β catalytic subunit (PP-1B) (EC 3.1.3.16) (EC 3.1.3.53), Ppp1cb |
| UniProt Protein Function: | PPP1CB: is a catalytic subunit of protein phosphatase 1 (PP1), a ubiquitous cytosolic serine-threonine phosphatase. Composed a catalytic subunit (PPP1CA, PPP1CB or PPP1CC) which is folded into its native form by inhibitor 2 and glycogen synthetase kinase 3, and then complexed to one or several targeting (or regulatory) subunits: PPP1R12A and PPP1R12B mediate binding to myosin; PPP1R3A, PPP1R3B, PPP1R3C and PPP1R3D mediate binding to glycogen; and PPP1R15A and PPP1R15B mediate binding to EIF2S1. PP1 is essential for cell division, plays critical roles in many cellular processes including glycogen metabolism, muscle contractility and protein synthesis, and is involved in the regulation of ionic conductances and long-term synaptic plasticity. Inhibits the synthesis of proteins involved in synaptic plasticity. Binds to the transcription factor cyclic AMP-dependent response element binding (CREB) and dephosphorylates it. May regulate chromatin condensation through regulation of histone H3 phosphorylation. Differentially expressed in gastric cancer. May participate in the neurodegenerative progress in Alzheimer's disease. Down-regulated in lung squamous cell carcinoma.Protein type: EC 3.1.3.16; EC 3.1.3.53; Motility/polarity/chemotaxis; Nucleolus; Protein phosphatase, Ser/Thr (non-receptor)Chromosomal Location of Human Ortholog: 5|5 B1Cellular Component: cytoplasm; focal adhesion; glycogen granule; nuclear chromosome, telomeric region; nucleus; protein phosphatase type 1 complexMolecular Function: myosin-light-chain-phosphatase activity; phosphoprotein phosphatase activity; phosphoric monoester hydrolase activity; protein binding; protein kinase binding; protein serine/threonine phosphatase activityBiological Process: circadian regulation of gene expression; entrainment of circadian clock by photoperiod; protein amino acid dephosphorylation; regulation of cell adhesion; regulation of circadian rhythm; regulation of glycogen biosynthetic process; regulation of glycogen catabolic process |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | P62141 |
| NCBI GenInfo Identifier: | 161484668 |
| NCBI Gene ID: | 19046 |
| NCBI Accession: | NP_766295.2 |
| UniProt Secondary Accession: | P62141,P37140, Q3TBE5, Q3TL90, Q542E7, Q8C285, Q9DBY2 |
| UniProt Related Accession: | P62141 |
| Molecular Weight: | 37,187 Da |
| NCBI Full Name: | serine/threonine-protein phosphatase PP1-beta catalytic subunit |
| NCBI Synonym Full Names: | protein phosphatase 1, catalytic subunit, beta isoform |
| NCBI Official Symbol: | Ppp1cb |
| NCBI Official Synonym Symbols: | 1200010B19 |
| NCBI Protein Information: | serine/threonine-protein phosphatase PP1-beta catalytic subunit |
| UniProt Protein Name: | Serine/threonine-protein phosphatase PP1-beta catalytic subunit |
| UniProt Synonym Protein Names: | |
| Protein Family: | Serine/threonine-protein phosphatase |
| UniProt Gene Name: | Ppp1cb |
| UniProt Entry Name: |
Related Products
Human TP53 antibody(p53 antibody) ELISA Kit
system_update_altDatasheet - तकनीकी मैनुअलsystem_update_altMSDS - तकनीक
OSTN Antibody
Overview Product Name:OSTN AntibodyProduct Code:PACO64881Size:50µLTarget Names:OSTNSpecies Reactivity:HumanHost
CYP2A13 Antibody
Overview Product Name:CYP2A13 AntibodyProduct Code:PACO64657Size:50µLTarget Names:CYP2A13Species Reactivity:Human, Mouse
OR13C8 Antibody
Overview Product Name:OR13C8 AntibodyProduct Code:PACO64869Size:50µLTarget Names:OR13C8Species Reactivity:HumanH
TTC14 Antibody
Overview Product Name:TTC14 AntibodyProduct Code:PACO64997Size:50µLTarget Names:TTC14Species Reactivity:HumanHos
SEZ6 Antibody
Overview Product Name:SEZ6 AntibodyProduct Code:PACO64941Size:50µLTarget Names:SEZ6Species Reactivity:HumanHost